What do systematic reviews say?

Methionine and supportive treatment vs supportive treatment

It is very uncertain whether methionine and supportive treatment changes mortality compared with supportive treatment (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.14 [0, 6.82]
  1 study · 26 participants
  Very low

Oral vs intravenous acetylcysteine

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 66 participants
  Very low

Intravenous acetylcysteine vs placebo

Intravenous acetylcysteine may leads to lower mortality compared with placebo (low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.29 [0.09, 0.94]
  1 study · 50 participants
  Low

Initial infusion rate of intravenous acetylcysteine over 15 minutes vs 60 minutes

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 180 participants
  Very low

Oral plus intravenous acetylcysteine vs intravenous acetylcysteine

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Very low

Charcoal haemoperfusion vs no intervention

It is very uncertain whether charcoal haemoperfusion changes mortality compared with no intervention (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 7.39 [0.15, 372.38]
  1 study · 16 participants
  Very low

Cysteamine vs no intervention

It is very uncertain whether cysteamine changes mortality compared with no intervention (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.53 [0.05, 5.22]
  2 studies · 65 participants
  Very low

Cysteamine vs dimercaprol

It is very uncertain whether cysteamine changes mortality compared with dimercaprol (very low certainty).

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  Peto OR 0.14 [0, 6.82]
  1 study · 52 participants
  Very low

Cysteamine vs methionine (randomised trials)

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 27 participants
  Very low

Standard intravenous acetylcysteine regimen (20.5 hour) vs shorter intravenous acetylcysteine regimen (12 hour)

• Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 222 participants
  Very low

N‐acetylcysteine vs placebo

N‐acetylcysteine showed no clear difference in all‐cause mortality compared with placebo (low certainty).

• N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure 2020 · Cochrane Headline outcomes only
  RR 0.88 [0.57, 1.37]
  1 study · 173 participants
  Low

N‐acetylcysteine vs placebo

N‐acetylcysteine showed no clear difference in all‐cause mortality compared with placebo (low certainty).

• N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure 2020 · Cochrane Headline outcomes only
  RR 1.47 [0.85, 2.53]
  1 study · 184 participants
  Low

Paracetamol vs ibuprofen

Paracetamol showed no clear difference in all‐cause mortality during initial hospital stay(by clinical… compared with ibuprofen (moderate certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 1.09 [0.8, 1.48]
  8 studies · 734 participants
  Moderate

Early paracetamol vs placebo or no intervention

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Late paracetamol vs placebo or no intervention

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

The review found no eligible studies for this question.

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Paracetamol vs indomethacin

Paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with indomethacin (low certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 0.86 [0.39, 1.92]
  2 studies · 114 participants
  Low

Prophylactic administration of paracetamol vs placebo or no intervention

Prophylactic administration of paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with placebo or no intervention (low certainty).

• Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
  RR 0.59 [0.24, 1.44]
  3 studies · 240 participants
  Low