Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

154 questions · 157 findings · 45 reviews

No studies found 40 · 25.5%GRADE not reported 31 · 19.7%Very low 24 · 15.3%Low 38 · 24.2%Moderate 23 · 14.6%High 1 · 0.6%

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Mortality at 6 months: main analysis · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis showed no clear difference in mortality at 6 months: main analysis compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality (deaths during trial period) · adults (> 18 years of age) with either COPD or recurrent acute exacerbations of chronic bronchitis

It is very uncertain whether the intervention changes mortality (deaths during trial period) (very low certainty).

1 finding from 1 review

ESA with or without iron vs no treatment

Overall mortality4 (Subnet based on 71 studies including 21,576 participants) · patients at any age with solid cancer or haematological malignancy

ESA with or without iron showed no clear difference in overall mortality4 (Subnet based on 71 studies including 21,576… compared with no treatment (low certainty).

1 finding from 1 review

ESA with or without iron vs no treatment

On‐study mortality3 (Subnet based on 55 studies including 15,074 participants) · patients at any age with solid cancer or haematological malignancy

ESA with or without iron showed no clear difference in on‐study mortality3 (Subnet based on 55 studies including 15,074… compared with no treatment (low certainty).

1 finding from 1 review