Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

154 questions · 157 findings · 45 reviews

No studies found 40 · 25.5%GRADE not reported 31 · 19.7%Very low 24 · 15.3%Low 38 · 24.2%Moderate 23 · 14.6%High 1 · 0.6%

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

All‐cause mortality · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis showed no clear difference in mortality compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Intervention not reported

Mortality · patients with venous leg ulcers

The review found no eligible studies for this question.

1 finding from 1 review

Totally percutaneous vs cut‐down femoral artery access

Short‐term mortality (30‐day or in‐hospital) · people undergoing elective bifurcated abdominal endovascular aneurysm repair

Totally percutaneous showed no clear difference in short‐term mortality (30‐day or in‐hospital) compared with cut‐down femoral artery access (low certainty).

1 finding from 1 review

Advanced haemodynamic monitoring vs protocol using standard measures such

All‐cause mortality Advanced haemodynamic monitoring · patients with proximal femoral fracture

It is very uncertain whether advanced haemodynamic monitoring changes all‐cause mortality Advanced haemodynamic monitoring compared with protocol using standard measures such (very low certainty).

1 finding from 1 review

Superselective neck dissection vs Elective selective neck dissection

Disease-free survival · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes
1 finding from 1 review

Sentinel node biopsy (neck dissection only if biopsy positive) vs Elective neck dissection

Disease-free survival · Adults with oral cavity or oropharyngeal cancer

Sentinel node biopsy (neck dissection only if biopsy positive) showed no clear difference in disease-free survival (new disease, progression, and mortality) compared with elective neck dissection (low certainty).

1 finding from 1 review

Elective neck dissection (at time of primary tumour resection) vs Therapeutic (delayed) neck dissection

Disease-free survival · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Elective neck dissection (at time of primary tumour resection) probably leads to lower disease-free survival (new disease, progression, and mortality) compared with therapeutic (delayed) neck dissection (moderate certainty).

1 finding from 1 review

Elective radical (comprehensive) neck dissection vs Elective selective neck dissection

Disease-free survival · Adults with oral cavity cancer

It is very uncertain whether elective radical (comprehensive) neck dissection changes disease-free survival (new disease, progression, and mortality) compared with elective selective neck dissection (very low certainty).

1 finding from 1 review