Findings

What do systematic reviews say?

187 questions · 189 findings · 84 reviews

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No studies found 16 · 8.5%GRADE not reported 7 · 3.7%Very low 44 · 23.3%Low 57 · 30.2%Moderate 47 · 24.9%High 18 · 9.5%

Intervention not reported

All‐cause mortality at 10 days ‐ short‐term treatment · patients with acute myocardial infarction1

The intervention showed no clear difference in all‐cause mortality at 10 days ‐ short‐term treatment (high certainty).

1 finding from 1 review

Effect of early treatment with anti‐hypertensive drugs on short and long‐term mortality in patients with an acute… 2009 · Cochrane Headline outcomes only
RR 0.96 [0.91, 1.02]
14 studies · 71457 participants
High

Intervention not reported

All‐cause mortality at 10 days ‐ short‐term treatment · patients with acute myocardial infarction or stroke1

It is very uncertain whether the intervention changes all‐cause mortality at 10 days ‐ short‐term treatment (very low certainty).

1 finding from 1 review

Effect of early treatment with anti‐hypertensive drugs on short and long‐term mortality in patients with an acute… 2009 · Cochrane Headline outcomes only
RR 1.01 [0.73, 1.38]
15 studies · 1900 participants
Very low

Intervention not reported

Mortality Death at any point during the trial duration · adult survivors of critical illness

1 finding from 1 review

Exercise rehabilitation following intensive care unit discharge for recovery from critical illness 2015 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 483 participants
Low

Intervention not reported

Mortality Study authors did not report final timepoint for data collection. · adult patients in the ICU

1 finding from 1 review

Melatonin for the promotion of sleep in adults in the intensive care unit 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 94 participants
Very low

HFNC vs NIPPV or NIV

In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with NIPPV or NIV (low certainty).

1 finding from 1 review

High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
RR 0.92 [0.64, 1.31]
5 studies · 1758 participants
Low

ICU follow‐up services vs standard care or no follow‐up service

All‐cause mortality Time point of measurement: 2 months in 1 randomised study; 12 months in 3 randomised studies; 14 months in 1 non‐randomised study · adult survivors of the ICU, excluding those already in an existing follow‐up or rehabilitation programme

1 finding from 1 review

Follow‐up services for improving long‐term outcomes in intensive care unit (ICU) survivors 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 1289 participants
Moderate

HFNC vs standard oxygen therapy

In‐hospital mortality (up to 90 days; included studies reported in‐hospital mortality, and mortality up to 28 days and up to ICU discharge) · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in in‐hospital mortality (up to 90 days; included studies reported… compared with standard oxygen therapy (moderate certainty).

1 finding from 1 review

High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
RR 0.96 [0.82, 1.11]
11 studies · 2673 participants
Moderate