evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

6 questions · 8 findings · 5 reviews

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 25%Low 3 · 37.5%Moderate 3 · 37.5%High 0 · 0%

Methotrexate vs placebo

Maintenance of clinical remission · Participants with Crohn's disease in remission

Methotrexate probably leads to higher proportion of patients maintaining clinical remission (high dose… compared with placebo (moderate certainty).

2 findings from 1 review

Any systemic treatment vs placebo

Methotrexate · people with chronic plaque psoriasis

Any systemic treatment may leads to higher methotrexate compared with placebo (low certainty).

2 findings from 1 review

Closed‐system transfer device plus safe handling vs safe handling alone

Methotrexate · healthcare staff who handle infusional hazardous drugs

It is very uncertain whether closed‐system transfer device plus safe handling changes methotrexate compared with safe handling alone (very low certainty).

1 finding from 1 review

Intervention not reported

Methotrexate (1 RCT; 50 participants) · patients with moderate to severe eczema

It is very uncertain whether the intervention changes methotrexate (1 RCT; 50 participants) (very low certainty).

1 finding from 1 review