Warfarin may leads to higher major bleeding eventsc compared with placebo or no treatment (low certainty).
It is very uncertain whether 10 mg warfarin nomogram changes minor bleeding it is not major bleeding compared with 5 mg warfarin nomogram (very low certainty).
10 mg warfarin nomogram showed no clear difference in major bleeding fall in hemoglobin of > 20 g/L or transfusion of 2 or… compared with 5 mg warfarin nomogram (moderate certainty).
Summary of findings: warfarin probably leads to higher major bleeding events compared with aspirin (moderate certainty).
Summary of findings: warfarin may leads to higher major bleeding events compared with clopidogrel (low certainty).
Direct oral anticoagulants (DOAC) showed no clear difference in major bleeding compared with warfarin (low certainty).
It is very uncertain whether fondaparinux changes major bleeding compared with variable dose warfarin (very low certainty).
It is very uncertain whether fondaparinux changes major bleeding compared with 1 mg warfarin (very low certainty).