Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Heart

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 2 · 100%High 0 · 0%

clopidogrel plus aspirin vs aspirin

Major bleeding · people with coronary disease, ischaemic cerebrovascular disease, peripheral arterial disease or at high risk of atherothrombotic disease

clopidogrel plus aspirin probably leads to higher major bleeding compared with aspirin alone (moderate certainty).

1 finding from 1 review

Clopidogrel plus aspirin versus aspirin alone for preventing cardiovascular events 2017 · Cochrane Headline outcomes only
RR 1.44 [1.25, 1.64]
10 studies · 33300 participants
Moderate

Warfarin vs aspirin

Major bleeding · patients with heart failure with sinus rhythm

Summary of findings: warfarin probably leads to higher major bleeding events compared with aspirin (moderate certainty).

1 finding from 1 review

Antiplatelet versus anticoagulation treatment for patients with heart failure in sinus rhythm 2016 · Cochrane Headline outcomes only
RR 2 [1.44, 2.78]
4 studies · 3663 participants
Moderate