Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

68 questions · 68 findings · 2 reviews

No studies found 15 · 22.1%GRADE not reported 5 · 7.4%Very low 2 · 2.9%Low 9 · 13.2%Moderate 27 · 39.7%High 10 · 14.7%

Intervention not reported

Dropouts due to adverse event ‐ MD TRIPLE vs MD‐ICS/LABA№ of participants: 3205(3 RCTs)

It is very uncertain whether the intervention changes dropouts due to adverse event ‐ MD TRIPLE vs MD‐ICS/LABA№ of… (very low certainty).

1 finding from 1 review

Intervention not reported

Moderate to severe exacerbations ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of participants: 5452(6 RCTs)

The intervention showed no clear difference in moderate to severe exacerbations ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of… (high certainty).

1 finding from 1 review