Findings

What do systematic reviews say?

8 questions · 11 findings · 4 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 36.4%Low 7 · 63.6%Moderate 0 · 0%High 0 · 0%

Metformin vs placebo or no treatment

Live birth rate per woman · women with polycystic ovary syndrome

Metformin showed no clear difference in live birth rate per woman compared with placebo or no treatment (low certainty).

1 finding from 1 review

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.59 [1, 2.51]
4 studies · 435 participants
Low

Metformin vs placebo or no treatment

Live birth rate per woman · Women with polycystic ovary syndrome, oligo amenorrhoea and subfertility

Metformin showed no clear difference in live birth rate per woman compared with placebo or no treatment (low certainty).

1 finding from 1 review

Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.59 [1, 2.51]
4 studies · 435 participants
Low

Metformin vs placebo co‐treatment

Live birth rate per woman · subfertile women with polycystic ovary syndrome

Metformin may leads to higher live birth rate (per woman) compared with placebo co‐treatment (low certainty).

1 finding from 1 review

Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination… 2017 · Cochrane Headline outcomes only
OR 2.31 [1.24, 4.33]
2 studies · 180 participants
Low

Metformin vs placebo or no treatment

Live birth rate per woman ‐ long protocol GnRH‐agonist · women with polycystic ovary syndrome

Metformin showed no clear difference in live birth rate per woman ‐ long protocol GnRH‐agonist compared with placebo or no treatment (low certainty).

1 finding from 1 review

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 1.3 [0.94, 1.79]
6 studies · 651 participants
Low

Metformin vs placebo or no treatment

Live birth rate per woman ‐ short protocol GnRH‐antagonist · women with polycystic ovary syndrome

Metformin may leads to lower live birth rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (low certainty).

1 finding from 1 review

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 0.48 [0.29, 0.79]
1 study · 153 participants
Low

Metformin vs clomiphene

Live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome

It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 0.3 [0.17, 0.52]
2 studies · 500 participants
Very low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 0.3 [0.17, 0.52]
2 studies · 500 participants
Very low

Metformin vs clomiphene

Live birth rate per woman aParticipants with BMI < 30 kg/m2 or ≤ 32 kg/m2 · women with polycystic ovary syndrome

It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI < 30 kg/m2 or ≤ 32… compared with clomiphene citrate (very low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.71 [1, 2.94]
3 studies · 241 participants
Very low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.71 [1, 2.94]
3 studies · 241 participants
Very low

Metformin combined with clomiphene citrate vs clomiphene

Live birth rate per woman · women with polycystic ovary syndrome

Metformin combined with clomiphene citrate showed no clear difference in live birth rate per woman compared with clomiphene citrate alone (low certainty).

2 findings from 2 reviews · compare the 2 reviews

Metformin for ovulation induction (excluding gonadotrophins) in women with polycystic ovary syndrome 2019 · Cochrane Headline outcomes only
OR 1.27 [0.98, 1.65]
10 studies · 1219 participants
Low
Insulin‐sensitising drugs (metformin, rosiglitazone, pioglitazone, D‐chiro‐inositol) for women with polycystic ovary… 2017 · Cochrane Headline outcomes only
OR 1.21 [0.92, 1.59]
9 studies · 1079 participants
Low