Findings

What do systematic reviews say?

7 questions · 10 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 30%Low 5 · 50%Moderate 2 · 20%High 0 · 0%

IUI in a stimulated cycle vs IUI

Live birth rate per couple · couples with male subfertility

It is very uncertain whether IUI in stimulated cycles changes live birth rate per couple (all cycles) compared with IUI (very low certainty).

1 finding from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 1.34 [0.77, 2.33]
Studies not reported
Very low

IUI in a natural cycle vs TI or expectant management

Live birth rate per couple · participants with unexplained subfertility

IUI in a natural cycle probably leads to higher live birth rate per couple (all cycles) compared with TI or expectant management (moderate certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.95 [1.1, 3.44]
1 study · 342 participants
Moderate

IUI in a stimulated cycle vs TI

Live birth rate per couple · couples with male subfertility

IUI in stimulated cycles showed no clear difference in live birth rate per couple (all cycles) compared with TI (low certainty).

2 findings from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 0.89 [0.3, 2.59]
Studies not reported
Low
Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 3.14 [0.12, 81.35]
Studies not reported
Very low

IUI in a natural cycle vs TI or expectant management

Live birth rate per couple (all cycles)‐ clomiphene citrate or letrozole · participants with unexplained subfertility

IUI in a natural cycle showed no clear difference in live birth rates per couple (all cycles) compared with TI or expectant management (low certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.6 [0.92, 2.78]
1 study · 334 participants
Low

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (low certainty).

2 findings from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 0.82 [0.45, 1.49]
1 study · 253 participants
Low
Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.59 [0.88, 2.88]
2 studies · 208 participants
Low

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple (all cycles)‐ clomiphene citrate or letrozole · participants with unexplained subfertility

IUI in a stimulated cycle probably leads to higher live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 4.48 [2, 10.01]
1 study · 201 participants
Moderate

IVF vs IUI

Live birth rate per couple · couples with male subfertility

IVF showed no clear difference in live birth rate per couple (all cycles) compared with IUI (low certainty).

2 findings from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 0.77 [0.25, 2.35]
Studies not reported
Low
Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 1.03 [0.43, 2.45]
Studies not reported
Very low