Findings

What do systematic reviews say?

7 questions · 7 findings · 6 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 28.6%Low 4 · 57.1%Moderate 1 · 14.3%High 0 · 0%

ART with seminal plasma vs standard ART (IVF, ICSI, and frozen embryo transfer)

Live birth or ongoing pregnancy · Women undergoing ART (IVF, ICSI, or frozen embryo transfer)

ART with seminal plasma showed no clear difference in live birth or ongoing pregnancy compared with standard ART (IVF, ICSI, and frozen embryo transfer) (low certainty).

1 finding from 1 review

Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology… 2018 · Cochrane Headline outcomes only
RR 1.19 [0.95, 1.49]
4 studies · 1178 participants
Low

ORT‐based algorithm vs standard dose of FSH

Live birth or ongoing pregnancy · Women undergoing IVF/ICSI cycles

ORT‐based algorithm showed no clear difference in live birth or ongoing pregnancy compared with standard starting dose of FSH (low certainty).

1 finding from 1 review

Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… 2024 · Cochrane Headline outcomes only
OR 1.12 [0.98, 1.29]
7 studies · 4400 participants
Low

RhCG vs uhCG

Ongoing pregnancy / live birth rate per woman · patients with final oocyte maturation triggering in IVF and ICSI cycles

RhCG showed no clear difference in ongoing pregnancy/live birth rate per woman compared with uhCG (moderate certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 1.15 [0.89, 1.49]
7 studies · 1136 participants
Moderate

RhLH vs uhCG

Ongoing pregnancy / live birth rate per woman · patients with final oocyte maturation triggering in IVF and ICSI cycles

It is very uncertain whether rhLH changes ongoing pregnancy/live birth rate per woman compared with uhCG (very low certainty).

1 finding from 1 review

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles 2016 · Cochrane Headline outcomes only
OR 0.95 [0.51, 1.78]
2 studies · 289 participants
Very low

Progesterone vs progesterone + GnRH agonist

Live birth or ongoing pregnancy · women who had undergone IVF/ICSI

It is very uncertain whether progesterone changes live birth or ongoing pregnancy compared with progesterone + GnRH agonist (very low certainty).

1 finding from 1 review

Luteal phase support for assisted reproduction cycles 2015 · Cochrane Headline outcomes only
OR 0.62 [0.48, 0.81]
9 studies · 2861 participants
Very low

Ultrasound‐guided embryo transfer vs clinical touch

Ongoing pregnancy / live birth rate per woman · Women undergoing embryo transfer as part of IVF or ICSI cycle

Ultrasound‐guided embryo transfer may leads to higher live birth and ongoing pregnancy (per woman randomised) compared with clinical touch (low certainty).

1 finding from 1 review

Ultrasound versus 'clinical touch' for catheter guidance during embryo transfer in women 2016 · Cochrane Headline outcomes only
OR 1.47 [1.3, 1.65]
13 studies · 5859 participants
Low

Metabolomics vs non metabolomics

Live birth or ongoing pregnancy · Women undergoing IVF/ICSI cycles

Metabolomics showed no clear difference in live birth rate or ongoing pregnancy (Delivery of a live fetus after… compared with non metabolomics (low certainty).

1 finding from 1 review

Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies 2018 · Cochrane Headline outcomes only
OR 1.02 [0.77, 1.35]
4 studies · 924 participants
Low