What do systematic reviews say?

4 questions · 4 findings · 3 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 1 · 25%High 1 · 25%

Insulin vs anti‐diabetic agent

Large‐for‐gestational age · Infants of women diagnosed with gestational diabetes

Insulin showed no clear difference in large‐for‐gestational age (birthweight > 90th centile) compared with anti‐diabetic agent (moderate certainty).

1 finding from 1 review

Insulin for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only
RR 1.01 [0.76, 1.35]
13 studies · 2352 participants
Moderate

Tight vs moderate glycaemic control (infant outcomes)

Large‐for‐gestational age · pregnant women with pre‐existing type 1 diabetes

1 finding from 1 review

Different intensities of glycaemic control for pregnant women with pre‐existing diabetes 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 45 participants
Very low

Tight‐moderate vs loose glycaemic control (infant outcomes)

Large‐for‐gestational age · pregnant women with pre‐existing type 1 diabetes

Tight‐moderate may leads to lower large‐for‐gestational age (birthweight > 90th centile) compared with loose glycaemic control (infant outcomes) (low certainty).

1 finding from 1 review

Different intensities of glycaemic control for pregnant women with pre‐existing diabetes 2016 · Cochrane Headline outcomes only
RR 0.01 [0, 0.2]
1 study · 60 participants
Low

Metformin vs placebo

Large‐for‐gestational age · women with obesity during pregnancy

Metformin showed no clear difference in large‐for‐gestational‐age infant, defined as birthweight ≥ 90th… compared with placebo (high certainty).

1 finding from 1 review

Metformin for women who are overweight or obese during pregnancy for improving maternal and infant outcomes 2018 · Cochrane Headline outcomes only
RR 0.95 [0.7, 1.3]
2 studies · 831 participants
High