Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

Oral anti‐diabetic pharmacological therapies vs placebo (outcomes

Large‐for‐gestational age · Infants of women diagnosed with gestational diabetes

It is very uncertain whether oral anti‐diabetic pharmacological therapies changes large‐for‐gestational age compared with placebo ‐ neonatal outcomes (very low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only
RR 0.89 [0.51, 1.58]
1 study · 375 participants
Very low

Metformin vs insulin

Large‐for‐gestational age · women with type 2 diabetes

It is very uncertain whether infant outcomes: oral anti‐diabetic agent (metformin) changes large‐for‐gestational age compared with insulin (very low certainty).

1 finding from 1 review

Oral anti‐diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational… 2017 · Cochrane Headline outcomes only
RR 1.12 [0.73, 1.72]
1 study · 206 participants
Very low

Metformin vs glibenclamide ‐ neonatal outcomes

Large‐for‐gestational age · Infants of women diagnosed with gestational diabetes

Metformin showed no clear difference in large‐for‐gestational age compared with glibenclamide ‐ neonatal outcomes (low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only
RR 0.67 [0.24, 1.83]
2 studies · 246 participants
Low

Glibenclamide vs acarbose ‐ neonatal outcomes

Large‐for‐gestational age · women with gestational diabetes mellitus

Glibenclamide showed no clear difference in large‐for‐gestational age compared with acarbose ‐ neonatal outcomes (low certainty).

1 finding from 1 review

Oral anti‐diabetic pharmacological therapies for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only
RR 2.38 [0.54, 10.46]
1 study · 43 participants
Low