Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews · Neonatal

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No studies found 1 · 25%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 25%Moderate 2 · 50%High 0 · 0%

Prophylactic or very early CPAP vs supportive care

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants

Prophylactic or very early CPAP showed no clear difference in intraventricular haemorrhage grade 3 or 4 compared with supportive care (low certainty).

1 finding from 1 review

Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants 2021 · Cochrane Headline outcomes only
RR 0.96 [0.39, 2.37]
2 studies · 486 participants
Low

Prophylactic CPAP vs very early CPAP

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Prophylactic CPAP vs mechanical ventilation

Intraventricular haemorrhage, Papile grade 3/4 · preterm infants

Prophylactic CPAP showed no clear difference in intraventricular haemorrhage grade 3 or 4 compared with mechanical ventilation (moderate certainty).

1 finding from 1 review

Prophylactic or very early initiation of continuous positive airway pressure (CPAP) for preterm infants 2021 · Cochrane Headline outcomes only
RR 1.09 [0.86, 1.39]
3 studies · 2301 participants
Moderate

Intervention not reported

Intraventricular haemorrhage (grades III and IV) · preterm infants with low birth weight

The intervention probably leads to lower intraventricular haemorrhage (grades III and IV) (moderate certainty).

1 finding from 1 review

Early erythropoiesis‐stimulating agents in preterm or low birth weight infants 2020 · Cochrane Headline outcomes only
RR 0.6 [0.43, 0.85]
8 studies · 1460 participants
Moderate