Findings

What do systematic reviews say?

2 questions · 2 findings · 2 reviews · Vascular

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 50%Moderate 1 · 50%High 0 · 0%

Corticosteroids vs no corticosteroid use

Incidence of coronary artery abnormalities · children diagnosed with Kawasaki disease

Corticosteroids probably leads to lower incidence of coronary artery abnormalities compared with no corticosteroid use (moderate certainty).

1 finding from 1 review

Corticosteroids for the treatment of Kawasaki disease in children 2022 · Cochrane Headline outcomes only
OR 0.32 [0.14, 0.75]
8 studies · 986 participants
Moderate

TNF‐α blockers intervention vs placebo or additional treatment

Incidence of coronary artery abnormalities · children diagnosed with Kawasaki disease

TNF‐α blockers intervention showed no clear difference in incidence of coronary artery abnormalities compared with placebo or additional treatment (low certainty).

1 finding from 1 review

TNF‐α blockers for the treatment of Kawasaki disease in children 2019 · Cochrane Headline outcomes only
RR 1.18 [0.45, 3.12]
3 studies · 270 participants
Low