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Evidence found and GRADE certainty

51 questions · 72 findings · 2 reviews · All outcomes

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No studies found 0 · 0%GRADE not reported 11 · 15.3%Very low 3 · 4.2%Low 17 · 23.6%Moderate 41 · 56.9%High 0 · 0%

Prior SDF application without a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Glass-ionomer cement bonded to caries-affected dentin (in vitro)

SDF pretreatment without a rinsing step does not affect glass-ionomer cement bond strength to caries-affected dentin (MD 0.26 MPa, 95% CI -0.30 to 0.82; ungraded).

1 finding from 1 review

Prior SDF application without a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Dental adhesives bonded to sound dentin (in vitro)

Prior SDF without a rinsing step significantly reduces adhesive bond strength to sound dentin (MD 17.52 MPa favoring untreated dentin, 95% CI 5.81 to 29.22; ungraded).

1 finding from 1 review

Prior application of silver diamine fluoride (SDF), with or without a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Dental adhesives/resin composite bonded to dentin (in vitro), sound or caries-affected

Prior SDF application significantly reduces the immediate bond strength of adhesives to dentin overall (MD 7.12 MPa favoring untreated dentin, 95% CI 1.38 to 12.85; ungraded), with very high heterogeneity (I2=98%).

1 finding from 1 review

Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Glass-ionomer cement bonded to sound dentin (in vitro)

SDF pretreatment with a rinsing step does not affect glass-ionomer cement bond strength to sound dentin (MD -1.11 MPa, 95% CI -3.47 to 1.25; ungraded).

1 finding from 1 review

Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Glass-ionomer cement bonded to caries-affected dentin (in vitro)

SDF pretreatment with a rinsing step does not affect glass-ionomer cement bond strength to caries-affected dentin (MD -0.36 MPa, 95% CI -1.07 to 0.35; ungraded).

1 finding from 1 review

Prior application of silver diamine fluoride (SDF), with or without a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Glass-ionomer cement bonded to dentin (in vitro), sound or caries-affected

Prior SDF application does not influence the immediate bond strength of glass-ionomer cement to dentin (MD -0.11 MPa, 95% CI -0.54 to 0.31; ungraded).

1 finding from 1 review

Prior SDF application without a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Glass-ionomer cement bonded to sound dentin (in vitro)

SDF pretreatment without a rinsing step does not affect glass-ionomer cement bond strength to sound dentin (MD 0.26 MPa, 95% CI -0.20 to 0.73; ungraded).

1 finding from 1 review

Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Dental adhesives bonded to sound dentin (in vitro)

A rinsing step after SDF eliminates the negative effect on adhesive bond strength to sound dentin (MD 7.11 MPa, 95% CI -0.57 to 14.79, non-significant; ungraded).

1 finding from 1 review

Prior SDF application with a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)

Prior SDF followed by a rinsing step significantly increases adhesive bond strength to caries-affected dentin (MD -4.79 MPa favoring SDF, 95% CI -9.19 to -0.40; ungraded).

1 finding from 1 review

Prior SDF application without a rinsing step vs No prior SDF application (untreated dentin control)

Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)

Only one study assessed SDF without a rinsing step on adhesive bonding to caries-affected dentin (Kucukyilmaz 2016, which reported impaired bond strength); no meta-analysis was possible, so no pooled estimate is available.

1 finding from 1 review

Mesoporous silica (SiO2) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Silica vs Fluorine showed no significant difference in 24 h bond strength (MD 1.441, 95% CI -5.099 to 7.980; Moderate certainty).

1 finding from 1 review

Hydroxyapatite (e.g., nano-HAp) vs Calcium-based agent

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HAp vs Calcium showed no significant difference in 24 h bond strength (MD -1.792, 95% CI -7.415 to 3.831; Low certainty).

2 findings from 1 review

Flavonoids (e.g., quercetin, proanthocyanidin) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Etch-and-Rinse adhesive + biological ACAD protocol network, Flavonoids vs Fluorine showed no significant difference in 24 h bond strength (MD 4.241, 95% CI -2.652 to 11.135; Moderate certainty).

2 findings from 1 review

Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Peptide vs Calcium Phosphate showed no significant difference in 24 h bond strength (MD -0.009, 95% CI -4.076 to 4.058; Low certainty).

3 findings from 1 review

HEMA/EGDMA-based desensitizer vs No biomimetic remineralization (control)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, HEMA vs Control showed no significant difference in 24 h bond strength (MD 1.899, 95% CI -3.210 to 7.009; Low certainty).

1 finding from 1 review

Calcium phosphate agent (e.g., CPP-ACP, Ca/P-PILP, niobophosphate) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Calcium Phosphate vs Fluorine showed no significant difference in 24 h bond strength (MD 2.140, 95% CI -1.506 to 5.787; Moderate certainty).

2 findings from 1 review

Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Calcium-based agent

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Peptide vs Calcium showed no significant difference in 24 h bond strength (MD 2.654, 95% CI -3.216 to 8.524; Moderate certainty).

2 findings from 1 review

Mesoporous silica (SiO2) vs Calcium-based agent

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Silica vs Calcium showed no significant difference in 24 h bond strength (MD 1.964, 95% CI -5.802 to 9.730; Moderate certainty).

1 finding from 1 review

Self-assembling/remineralizing peptide (e.g., P11-4, PAA-PASP) vs Fluoride agent (e.g., NaF/SDF/KF/CaF2)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Self-Etch adhesive + chemical ACAD protocol network, Peptide vs Fluorine showed no significant difference in 24 h bond strength (MD 2.131, 95% CI -2.213 to 6.475; Low certainty).

3 findings from 1 review