Findings

What do systematic reviews say?

16 questions · 16 findings · 7 reviews · Pain, Palliative and Supportive Care

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No studies found 2 · 12.5%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 12.5%Moderate 7 · 43.8%High 5 · 31.3%

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

Headache relief at 2 h for moderate to severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Sumatriptan 50 mg or 85 mg plus naproxen 500 mg vs placebo

Sustained headache relief during the 24 h post dose for moderate or severe baseline pain · adults with migraine headache ‐ moderate or severe and mild baseline pain

1 finding from 1 review

Sumatriptan plus naproxen for the treatment of acute migraine attacks in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Intervention not reported

Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Zolmitriptan for acute migraine attacks in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Intervention not reported

Headache relief at 1 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Zolmitriptan for acute migraine attacks in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Intervention not reported

Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Ibuprofen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Intervention not reported

Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Headache relief at 1 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Headache relief at 2 h · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Aspirin with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 2027 participants
Moderate

Intervention not reported

Headache relief at 2 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Diclofenac with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1447 participants
Moderate

Naproxen 500 mg or 825 mg vs placebo

Headache relief at 2 h · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Intervention not reported

Sustained headache relief at 24 h · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Ibuprofen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Intervention not reported

Sustained headache relief at 24 h · adults with migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Sustained headache relief at 24 h · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Aspirin with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1142 participants
Moderate

Intervention not reported

Sustained headache relief at 24 h · adults with migraine headache ‐ moderate or severe pain

The review found no eligible studies for this question.

1 finding from 1 review

Diclofenac with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Sustained headache relief during the 24 h post dose · adults with migraine headache ‐ moderate or severe pain

1 finding from 1 review

Zolmitriptan for acute migraine attacks in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
High

Naproxen 500 mg or 825 mg vs placebo

Sustained headache relief at 24 h · migraine headache ‐ moderate or severe pain

1 finding from 1 review

Naproxen with or without an antiemetic for acute migraine headaches in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate