Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Gut

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Proton pump inhibitors (PPI) vs H2 receptor antagonists (H2RA)

Global symptoms of dyspepsia · adults with functional dyspepsia

Proton pump inhibitors (PPI) showed no clear difference in global symptoms of dyspepsia compared with H2 receptor antagonists (H2RA) (low certainty).

1 finding from 1 review

Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only
RR 0.88 [0.74, 1.04]
2 studies · 740 participants
Low

Proton pump inhibitors (PPI) vs prokinetics

Global symptoms of dyspepsia · adults with functional dyspepsia

Proton pump inhibitors (PPI) may leads to lower global symptoms of dyspepsia compared with prokinetics (low certainty).

1 finding from 1 review

Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only
RR 0.89 [0.81, 0.99]
5 studies · 1033 participants
Low

Proton pump inhibitors (PPI) vs placebo

Global symptoms of dyspepsia · patients with functional dyspepsia

Proton pump inhibitors (PPI) probably leads to lower global symptoms of dyspepsia (> 2 weeks) compared with placebo (moderate certainty).

1 finding from 1 review

Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only
RR 0.88 [0.82, 0.94]
18 studies · 6172 participants
Moderate

Proton pump inhibitors plus prokinetics vs prokinetics

Global symptoms of dyspepsia · adults with functional dyspepsia

Proton pump inhibitors plus prokinetics showed no clear difference in global symptoms of dyspepsia compared with prokinetics alone (moderate certainty).

1 finding from 1 review

Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only
RR 0.85 [0.68, 1.08]
2 studies · 407 participants
Moderate