What do systematic reviews say?

HALOPERIDOL vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

It is very uncertain whether HALOPERIDOL changes global outcome compared with COMBINATIONS: c. HALOPERIDOL + MIDAZOLAM (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.29 [0.13, 0.61]
  1 study · 60 participants
  Very low

HALOPERIDOL vs COMBINATIONS: e. HALOPERIDOL + RISPERIDONE

HALOPERIDOL showed no clear difference in global outcome compared with COMBINATIONS: e. HALOPERIDOL + RISPERIDONE (low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.38 [0.11, 1.33]
  1 study · 100 participants
  Low

HALOPERIDOL vs COMBINATIONS: c. HALOPERIDOL + PROMETHAZINE

HALOPERIDOL showed no clear difference in global outcomes compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (moderate certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 1.21 [0.84, 1.76]
  1 study · 316 participants
  Moderate

HALOPERIDOL vs COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE

It is very uncertain whether HALOPERIDOL changes global outcome: general ‐ no overall improvement compared with COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 8.18 [0.5, 133.66]
  1 study · 19 participants
  Very low

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

It is very uncertain whether HALOPERIDOL changes global outcome: no overall improvement ‐ at 30 minutes compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 2.67 [1.25, 5.68]
  1 study · 45 participants
  Very low

HALOPERIDOL vs COMBINATIONS: f. OLANZAPINE + MAGNESIUM VALPROATE

It is very uncertain whether HALOPERIDOL changes global outcome compared with COMBINATIONS: f. OLANZAPINE + MAGNESIUM VALPROATE (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 1.06 [0.38, 2.95]
  1 study · 64 participants
  Very low

HALOPERIDOL vs COMBINATIONS: h. RISPERIDONE + CLONAZEPAM

HALOPERIDOL showed no clear difference in global outcome compared with COMBINATIONS: h. RISPERIDONE + CLONAZEPAM (low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.6 [0.15, 2.38]
  1 study · 100 participants
  Low

HALOPERIDOL vs ZIPRASIDONE

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 132 participants
  Very low

HALOPERIDOL vs QUETIAPINE

The review found no eligible studies for this question.

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: j. ZUCLOPENTHIXOL ACETATE

The review found no eligible studies for this question.

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

HALOPERIDOL vs midazolam

HALOPERIDOL showed no clear difference in global outcome Need for rescue drug compared with BENZODIAZEPINE: c. MIDAZOLAM (low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 1.14 [0.46, 2.87]
  1 study · 84 participants
  Low

HALOPERIDOL vs chlorpromazine

It is very uncertain whether HALOPERIDOL changes global outcome ‐ not any improvement compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.15 [0.05, 0.49]
  2 studies · 89 participants
  Very low

HALOPERIDOL vs OTHER ANTIPSYCHOTICS

HALOPERIDOL leads to lower global outcomes ‐ overall improvement compared with OTHER ANTIPSYCHOTICS (high certainty).

• Haloperidol for long‐term aggression in psychosis 2016 · Cochrane Headline outcomes only
  no estimate extracted
  83 participants
  High

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: h. THIOTHIXENE

It is very uncertain whether HALOPERIDOL changes global outcome No improvement at 1 hour compared with OTHER ANTIPSYCHOTIC: i. THIOTHIXENE (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.5 [0.14, 1.84]
  1 study · 44 participants
  Very low

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: c. DROPERIDOL

HALOPERIDOL showed no clear difference in global outcome ‐ need for benzodiazepine compared with OTHER ANTIPSYCHOTIC: c. DROPERIDOL (moderate certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.31 [0.07, 1.44]
  1 study · 228 participants
  Moderate

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: f. PERPHENAZINE

It is very uncertain whether HALOPERIDOL changes global outcome: general ‐ no improvement compared with OTHER ANTIPSYCHOTIC: f. PERPHENAZINE (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.46 [0.04, 4.68]
  1 study · 44 participants
  Very low

HALOPERIDOL vs RISPERIDONE

It is very uncertain whether HALOPERIDOL changes global outcome ‐ rated as severe ‐ CGI‐S compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.89 [0.51, 1.58]
  1 study · 162 participants
  Very low

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: d. LOXAPINE

HALOPERIDOL showed no clear difference in global outcome: no change at 48 hours CGI compared with OTHER ANTIPSYCHOTIC: d. LOXAPINE (low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.93 [0.14, 6.15]
  1 study · 56 participants
  Low

HALOPERIDOL vs ARIPIPRAZOLE

It is very uncertain whether HALOPERIDOL changes global outcomes: need for benzodiazepine 2 compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 1.26 [0.74, 2.16]
  2 studies · 477 participants
  Very low

HALOPERIDOL vs COMBINATIONS: i. ZIPRASIDONE + CLONAZEPAM

The review found no eligible studies for this question.

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found