What do systematic reviews say?

HALOPERIDOL vs ANTIPSYCHOTIC & BENZODIAZEPINE ‐ HALOPERIDOL + MIDAZOLAM

It is very uncertain whether HALOPERIDOL changes global outcome compared with COMBINATIONS: c. HALOPERIDOL + MIDAZOLAM (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.29 [0.13, 0.61]
  1 study · 60 participants
  Very low

HALOPERIDOL vs COMBINATIONS: e. HALOPERIDOL + RISPERIDONE

HALOPERIDOL showed no clear difference in global outcome compared with COMBINATIONS: e. HALOPERIDOL + RISPERIDONE (low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.38 [0.11, 1.33]
  1 study · 100 participants
  Low

HALOPERIDOL vs COMBINATIONS: f. OLANZAPINE + MAGNESIUM VALPROATE

It is very uncertain whether HALOPERIDOL changes global outcome compared with COMBINATIONS: f. OLANZAPINE + MAGNESIUM VALPROATE (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 1.06 [0.38, 2.95]
  1 study · 64 participants
  Very low

HALOPERIDOL vs COMBINATIONS: h. RISPERIDONE + CLONAZEPAM

HALOPERIDOL showed no clear difference in global outcome compared with COMBINATIONS: h. RISPERIDONE + CLONAZEPAM (low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 0.6 [0.15, 2.38]
  1 study · 100 participants
  Low

HALOPERIDOL vs COMBINATIONS: c. HALOPERIDOL + PROMETHAZINE

HALOPERIDOL showed no clear difference in global outcomes compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (moderate certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 1.21 [0.84, 1.76]
  1 study · 316 participants
  Moderate

RISPERIDONE vs COMBINATION: b. RISPERIDONE + VALPROIC ACID

The review found no eligible studies for this question.

• Risperidone for psychosis‐induced aggression or agitation (rapid tranquillisation) 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

RISPERIDONE vs COMBINATION: a. RISPERIDONE + OXCARBAZEPINE

• Risperidone for psychosis‐induced aggression or agitation (rapid tranquillisation) 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 68 participants
  Very low

HALOPERIDOL vs COMBINATIONS: i. ZIPRASIDONE + CLONAZEPAM

The review found no eligible studies for this question.

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

HALOPERIDOL vs COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE

It is very uncertain whether HALOPERIDOL changes global outcome: general ‐ no overall improvement compared with COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 8.18 [0.5, 133.66]
  1 study · 19 participants
  Very low

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

It is very uncertain whether HALOPERIDOL changes global outcome: no overall improvement ‐ at 30 minutes compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

• Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
  RR 2.67 [1.25, 5.68]
  1 study · 45 participants
  Very low