What do systematic reviews say?

Sildenafil vs IV nitroglycerin

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Sildenafil vs Placebo or no active treatment

Sildenafil citrate showed no clear difference in fetal mortality compared with placebo or no therapy (moderate certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 0.82 [0.6, 1.12]
  5 studies · 516 participants
  Moderate

Tadalafil vs Placebo or no active treatment

Tadalafil showed no clear difference in fetal mortality compared with placebo or no therapy (low certainty).

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  RR 0.11 [0.01, 1.96]
  1 study · 87 participants
  Low

Nitroglycerin vs Placebo or no active treatment

• Interventions affecting the nitric oxide pathway versus placebo or no therapy for fetal growth restriction in pregnancy 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 23 participants
  Low

Lifestyle vs control ‐ Neonatal and later outcomes

Lifestyle showed no clear difference in perinatal (fetal and neonatal death) and later infant mortality compared with control ‐ Neonatal and later outcomes (low certainty).

• Lifestyle interventions for the treatment of women with gestational diabetes 2017 · Cochrane Headline outcomes only
  RR 0.09 [0.01, 1.7]
  2 studies · 1988 participants
  Low