Findings

What do systematic reviews say?

17 questions · 18 findings · 9 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 1 · 5.6%GRADE not reported 1 · 5.6%Very low 9 · 50%Low 4 · 22.2%Moderate 3 · 16.7%High 0 · 0%

Music intervention plus standard care vs usual care

Fatigue · children with cancer

1 finding from 1 review

Music interventions for improving psychological and physical outcomes in people with cancer 2021 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Music intervention plus standard care vs usual care

Fatigue · adult cancer patients (≥ 18 years)

1 finding from 1 review

Music interventions for improving psychological and physical outcomes in people with cancer 2021 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 498 participants
Low

Intervention not reported

Fatigue · individuals with any cancer at any stage

1 finding from 1 review

Telephone interventions for symptom management in adults with cancer 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 895 participants
Very low

Exercise vs usual care

Fatigue · People with cancer undergoing multimodal treatment including surgery

1 finding from 1 review

Exercise interventions for people undergoing multimodal cancer treatment that includes surgery 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 449 participants
Moderate

Intervention not reported

Overall fatigue · people who are undergoing active treatment for cancer

1 finding from 1 review

Exercise interventions on health‐related quality of life for people with cancer during active treatment 2012 · Cochrane Headline outcomes only
no estimate extracted
23 studies · 1721 participants
Very low

Imiquimod vs cidofovir

Fatigue · women with usual‐type vulval intraepithelial neoplasia

Summary of findings for imiquimod probably leads to higher fatigue ‐ any grade compared with cidofovir (moderate certainty).

1 finding from 1 review

Medical and surgical interventions for the treatment of usual‐type vulval intraepithelial neoplasia 2016 · Cochrane Headline outcomes only
RR 1.25 [1.02, 1.55]
1 study · 168 participants
Moderate

Imiquimod vs cidofovir

Fatigue · women with high‐grade VIN

The review found no eligible studies for this question.

1 finding from 1 review

Medical interventions for high‐grade vulval intraepithelial neoplasia 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Laigle‐Donadey 2019: dexamfetamine sulfate vs placebo

Fatigue · people with a primary brain tumour

2 findings from 1 review

Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 41 participants
Very low
Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 41 participants
Very low

Modafinil vs placebo

Fatigue –severity Subscale from CIS · people with a primary brain tumour

1 finding from 1 review

Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Very low

Intervention not reported

Overall fatigue change ‐ Up to 12 weeks' · Cancer survivors who have completed active cancer treatment

1 finding from 1 review

Exercise interventions on health‐related quality of life for cancer survivors 2012 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 745 participants
Moderate

Modafinil vs placebo

Fatigue –reduced activity Subscale from CIS · people with a primary brain tumour

1 finding from 1 review

Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Very low

Modafinil vs placebo

Fatigue –reduced motivation Subscale from CIS · people with a primary brain tumour

1 finding from 1 review

Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Very low

Intervention not reported

Overall fatigue change score ‐ up to 12 weeks' · people who are undergoing active treatment for cancer

1 finding from 1 review

Exercise interventions on health‐related quality of life for people with cancer during active treatment 2012 · Cochrane Headline outcomes only
no estimate extracted
12 studies · 971 participants
Very low

Modafinil vs placebo

Fatigue –concentration problems Subscale from CIS · people with a primary brain tumour

1 finding from 1 review

Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 37 participants
Very low

Intervention not reported

Overall fatigue change ‐ More than 12 weeks less than 6 months' · Cancer survivors who have completed active cancer treatment

1 finding from 1 review

Exercise interventions on health‐related quality of life for cancer survivors 2012 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 246 participants
Low

Exercise vs no exercise

Fatigue · adults with breast or prostate cancer receiving radiation therapy alone

1 finding from 1 review

Exercise interventions for adults with cancer receiving radiation therapy alone 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 112 participants
Low

Porter 2020: armodafinil vs placebo

Fatigue · people with a primary brain tumour

1 finding from 1 review

Interventions for the management of fatigue in adults with a primary brain tumour 2022 · Cochrane Headline outcomes only
no estimate extracted
1 study · 297 participants
Low