What do systematic reviews say?

Exercise prescription plus the use of a wearable fitness tracker vs exercise

• Digital technology for delivering and monitoring exercise programs for people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 40 participants
  Very low

Summary of findings: inhaled TOBI® (IV preparation) vs tobramycin

• Inhaled anti‐pseudomonal antibiotics for long‐term therapy in cystic fibrosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 32 participants
  Very low

14 days inhaled AZLI plus 14 days placebo vs 28 days inhaled AZLI

The review found no eligible studies for this question.

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Autogenic drainage vs spontaneous cough

• Autogenic drainage for airway clearance in cystic fibrosis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 14 participants
  Very low

Omega‐3 vs placebo

It is very uncertain whether summary of findings: omega‐3 fatty acid supplementation changes FEV1 % predicted compared with placebo (very low certainty).

• Omega‐3 fatty acid supplementation for cystic fibrosis 2020 · Cochrane Headline outcomes only
  MD 2 [19.11, 23.11]
  1 study · 17 participants
  Very low

Summary of findings: NPH insulin vs insulin glargine

The review found no eligible studies for this question.

• Drug treatments for managing cystic fibrosis‐related diabetes 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Respiratory muscle training vs control

• Respiratory muscle training for cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 83 participants
  Very low

Inhalation before vs during airway clearance techniques

• Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 63 participants
  Low

Inhalation during vs after airway clearance techniques

• Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 50 participants
  Low

Inhalation before vs after airway clearance techniques

• Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 50 participants
  Low

Summary of findings ‐ high‐dose azithromycin vs low‐dose azithromycin

• Macrolide antibiotics (including azithromycin) for cystic fibrosis 2024 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 47 participants
  Very low

CCPT vs AD

• Conventional chest physiotherapy compared to other airway clearance techniques for cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 54 participants
  Very low

Inhaled tobramycin (TNS) (28 days) vs TNS (56 days)

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 88 participants
  Very low

Standard rhGH vs no treatment

• Recombinant growth hormone therapy for cystic fibrosis in children and young adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 19 participants
  Very low

Oscillating devices vs PEP

• Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  15 studies · 510 participants
  Very low

Oscillating devices vs conventional physiotherapy

• Oscillating devices for airway clearance in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 363 participants
  Very low

Summary of findings ‐ PEP vs PDPV

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 155 participants
  Low

Summary of findings ‐ PEP vs HFCWO

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 174 participants
  Low

Summary of findings ‐ PEP vs airway clearance techniques

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  95 participants
  Low

Summary of findings ‐ PEP vs oscillating PEP

• Positive expiratory pressure physiotherapy for airway clearance in people with cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 217 participants
  Moderate