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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 9 findings · 2 reviews · Airways

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No studies found 3 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 22.2%Moderate 3 · 33.3%High 1 · 11.1%

14 days on/off antibiotic regimen vs 14 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

14 days on/off antibiotic regimen probably leads to lower exacerbation frequency compared with 14 days on/off placebo regimen (moderate certainty).

2 findings from 1 review

14 days on/off antibiotic regimen vs 28 days on/off antibiotic regimen

Exacerbation frequency · people with bronchiectasis

14 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off antibiotic regimen (moderate certainty).

2 findings from 1 review

28 days on/off antibiotic regimen vs 28 days on/off placebo regimen

Exacerbation frequency · people with bronchiectasis

28 days on/off antibiotic regimen showed no clear difference in exacerbation frequency compared with 28 days on/off placebo regimen (high certainty).

2 findings from 1 review

Macrolides vs placebo

Exacerbation frequency · children with bronchiectasis

Macrolides may leads to lower exacerbation frequency compared with placebo (low certainty).

1 finding from 1 review