Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

59 questions · 62 findings · 25 reviews

No studies found 1 · 1.6%GRADE not reported 5 · 8.1%Very low 28 · 45.2%Low 17 · 27.4%Moderate 11 · 17.7%High 0 · 0%

Integrated CBT vs Twelve Step Facilitation

Depression score · co‐occurring depression and substance use disorders
2 findings from 1 review

Psychological interventions vs usual care

Change in depression score ( · adolescents and adults with congenital heart disease
2 findings from 1 review

Non‐invasive brain stimulation and pharmacological intervention (combination) vs a pharmacological intervention and sham stimulation or usual care (single)

Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke
1 finding from 1 review

Repetitive transcranial magnetic stimulation (rTMS) vs rTMS plus Tricyclic Anti‐depressant

Depression rating scale score · Post‐TBI Depression

It is very uncertain whether repetitive transcranial magnetic stimulation (rTMS) changes hamilton Rating Scale for Depression (HAM‐D); higher score means… compared with rTMS plus Tricyclic Anti‐depressant (very low certainty).

1 finding from 1 review

Pharmacological intervention and a form of psychotherapy (combination) vs pharmacological intervention and usual care or attention control (single)

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke
1 finding from 1 review