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Evidence found and GRADE certainty

132 questions · 185 findings · 31 reviews

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No studies found 1 · 0.5%GRADE not reported 164 · 88.6%Very low 18 · 9.7%Low 1 · 0.5%Moderate 1 · 0.5%High 0 · 0%

Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions

DMFT/DMFS index (dental caries experience) · Children aged 0-12 years (studies published 2015 or later)

In studies published from 2015 onward, OHPPs were associated with lower DMFT (OR 0.08, 95% CI 0.01 to 0.53; ungraded).

1 finding from 1 review

Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions

DMFT/DMFS index (dental caries experience) · Children aged 0-12 years in Finland

The single Finnish study showed lower DMFT/S with OHPP (OR 0.48, 95% CI 0.41 to 0.56; ungraded, single study).

1 finding from 1 review

Oral-health promotion programs (OHPPs): community-based oral-health education/training, supervised toothbrushing with fluoride toothpaste and topical fluoride, dental screening, and dietary advice vs No oral-health promotion program, or a differing (usual-care) action under similar conditions

DMFT/DMFS index (dental caries experience) · Children aged 0-12 years (studies published before 2015)

In studies published before 2015, OHPPs were associated with lower DMFT (OR 0.01, 95% CI 0.00 to 0.13; ungraded).

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs HIV-negative individuals

Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)

In cross-sectional studies, children and adolescents with HIV on antiretroviral therapy had about twice the odds of dental caries versus HIV-negative peers (OR 2.04, 95% CI 1.21 to 3.42; very low certainty).

3 findings from 1 review

TT genotype vs TC+CC genotypes

Dental caries · Children (<18 years) with vs without dental caries

In the PCR-RFLP genotyping subgroup, TaqI(rs731236) recessive model: TT vs TC+CC showed no significant association with caries (OR 1.49); ungraded.

8 findings from 1 review
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TT+TC genotypes vs CC genotype

Dental caries · Children (<18 years) with vs without dental caries

In the Caucasian ethnicity subgroup, TaqI(rs731236) dominant model: TT+TC vs CC showed no significant association with caries (OR 0.84); ungraded.

8 findings from 1 review
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TT genotype vs TG+GG genotypes

Dental caries · Children (<18 years) with vs without dental caries

TaqI/BglI(rs739837) recessive model: TT vs TG+GG was not significantly associated with dental caries (OR 0.93); ungraded.

1 finding from 1 review

G allele vs A allele

Dental caries · Children (<18 years) with vs without dental caries

BsmI(rs1544410) allele distribution (G vs A) was not significantly associated with caries (OR 1.56; high heterogeneity); ungraded.

1 finding from 1 review

CC genotype vs CA+AA genotypes

Dental caries · Children (<18 years) with vs without dental caries

ApaI(rs7975232) recessive model: CC vs CA+AA was not significantly associated with dental caries (OR 0.87); ungraded.

1 finding from 1 review

T allele vs G allele

Dental caries · Children (<18 years) with vs without dental caries

TaqI/BglI(rs739837) allelic model: T vs G was not significantly associated with dental caries (OR 1.00); ungraded.

1 finding from 1 review

T allele vs C allele

Dental caries · Children (<18 years) with vs without dental caries

In the Permanent dentition subgroup, TaqI(rs731236) allelic model: T vs C showed no significant association with caries (OR 0.90); ungraded.

8 findings from 1 review
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C allele vs T allele

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs10735810) C allele was significantly associated with higher caries risk vs T allele (pooled OR 1.33, 95% CI 1.03-1.71); ungraded.

1 finding from 1 review

CC+CT genotypes vs TT genotype

Dental caries · Children (<18 years) with vs without dental caries

CC+CT genotype at FokI(rs10735810) was associated with ~1.87-fold higher caries risk than TT (dominant model, OR 1.87); ungraded.

1 finding from 1 review

AA genotype vs AG+GG genotypes

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) recessive model: AA vs AG+GG was not significantly associated with dental caries (OR 1.09); ungraded.

1 finding from 1 review

TT+CC (homozygous) genotypes vs TC (heterozygous) genotype

Dental caries · Children (<18 years) with vs without dental caries

In the Real-time quantitative PCR genotyping subgroup, TaqI(rs731236) over-dominant model: TT+CC vs TC showed a significant association with caries (OR 1.52); ungraded.

8 findings from 1 review
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AA+AG genotypes vs GG genotype

Dental caries · Children (<18 years) with vs without dental caries

FokI(rs2228570) dominant model: AA+AG vs GG was not significantly associated with dental caries (OR 1.07); ungraded.

1 finding from 1 review

CC+CA genotypes vs AA genotype

Dental caries · Children (<18 years) with vs without dental caries

ApaI(rs7975232) dominant model: CC+CA vs AA was not significantly associated with dental caries (OR 0.91); ungraded.

1 finding from 1 review

Cdx-2(rs11568820) A allele / genotype vs G allele

Dental caries · Children (<18 years) with vs without dental caries

Cdx-2(rs11568820) was reported by only one study and was not meta-analyzed; its association with caries risk is uncertain (ungraded).

1 finding from 1 review

TT+TG genotypes vs GG genotype

Dental caries · Children (<18 years) with vs without dental caries

TaqI/BglI(rs739837) dominant model: TT+TG vs GG was not significantly associated with dental caries (OR 1.09); ungraded.

1 finding from 1 review

GG genotype vs GA+AA genotypes

Dental caries · Children (<18 years) with vs without dental caries

After removing Zhang 2006, the recessive model at BsmI(rs1544410) remained non-significant (OR 0.86); ungraded.

2 findings from 1 review