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Evidence found and GRADE certainty

334 questions · 707 findings · 50 reviews

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No studies found 3 · 0.4%GRADE not reported 667 · 94.3%Very low 31 · 4.4%Low 4 · 0.6%Moderate 2 · 0.3%High 0 · 0%

Responsive complementary feeding (RCF) / other caregivers' feeding practices vs Other models of complementary feeding (traditional/non-responsive CF)

Dental caries · Healthy, term-born, normal-birth-weight infants aged 4-24 months (breastfed and/or formula-fed) in Western industrialized countries

No eligible studies examined the influence of complementary feeding practices on later dental caries; this is an evidence gap.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Australia, the pooled prevalence of primary-teeth caries in children was 28.5% (95% CI 20.3 to 38.5); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Africa, the pooled prevalence of primary-teeth caries in children was 53.1% (95% CI 44.3 to 61.7); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Asia, the pooled prevalence of primary-teeth caries in children was 52.6% (95% CI 46.7 to 58.5); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In Europe, the pooled prevalence of primary-teeth caries in children was 21.4% (95% CI 15.3 to 29.1); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

In the Americas, the pooled prevalence of primary-teeth caries in children was 45.8% (95% CI 34.2 to 58.0); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in primary teeth · Children (primary dentition) worldwide

The pooled worldwide prevalence of dental caries in primary teeth in children was 46.2% (95% CI 41.6 to 50.8), with very high heterogeneity (I2=99.2%); certainty not graded.

1 finding from 1 review

Populations in countries with a lower Human Development Index (high category, HDI <0.800) vs Populations in countries with a higher Human Development Index (very high, HDI >=0.800)

Caries experience (mean DMFT) · Adults aged 19-60 years

Pooled caries experience (DMFT) was similar in very-high-HDI and high-HDI countries, and meta-regression found no significant association between national HDI and DMFT; ungraded observational evidence with very high heterogeneity.

3 findings from 1 review

HIV-infected children on antiretroviral therapy (HI) vs HIV-exposed but uninfected children (HEU)

Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)

HIV-infected children on ART had higher odds of dental caries than HEU children in a cohort study (OR 2.88, 95% CI 1.71 to 4.84; ungraded).

2 findings from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs HIV-negative individuals

Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)

In cross-sectional studies, children and adolescents with HIV on antiretroviral therapy had about twice the odds of dental caries versus HIV-negative peers (OR 2.04, 95% CI 1.21 to 3.42; very low certainty).

3 findings from 1 review

HAART (highly active antiretroviral therapy, >=3 drugs) vs HIV-positive not receiving HAART (standard ART or HAART-naive)

Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)

Among HIV+ children, HAART versus no HAART showed no significant difference in the odds of dental caries by DMFT in cross-sectional studies (OR 1.29, 95% CI 0.59 to 2.84; ungraded).

2 findings from 1 review

HIV-infected children on antiretroviral therapy (HI) vs HIV-unexposed uninfected children (HUU)

Dental caries · Children and adolescents (<18 years) living with HIV (CLWH)

HIV-infected children on ART had higher odds of dental caries than HUU children in case-control studies (OR 1.61, 95% CI 1.02 to 2.56; ungraded).

2 findings from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In Africa, the pooled prevalence of permanent-teeth caries in children was 58.9% (95% CI 29.4 to 83.1); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In Europe, the pooled prevalence of permanent-teeth caries in children was 44.1% (95% CI 36.1 to 52.5); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In Australia, the pooled estimate of permanent-teeth caries prevalence in children was 54.9% (95% CI 50.9 to 58.8) from a single study; certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

The pooled worldwide prevalence of dental caries in permanent teeth in children was 53.8% (95% CI 50.0 to 57.5), with very high heterogeneity (I2=99.8%); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In the Americas, the pooled prevalence of permanent-teeth caries in children was 48.9% (95% CI 37.6 to 60.3); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries in permanent teeth · Children (permanent dentition) worldwide

In Asia, the pooled prevalence of permanent-teeth caries in children was 58.8% (95% CI 53.4 to 64.0); certainty not graded.

1 finding from 1 review