What do systematic reviews say?

Fish oil lipid emulsion (LE) vs non‐fish oil LE

It is very uncertain whether fish oil LE changes death before discharge compared with non‐fish oil LE (very low certainty).

• Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
  RR 0.24 [0.03, 1.87]
  2 studies · 40 participants
  Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

• Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 68 participants
  GRADE not reported

MOFS‐LE vs S‐LE

MOFS‐LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 1.26 [0.68, 2.31]
  5 studies · 369 participants
  Low

MS‐LE vs S‐LE

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  GRADE not reported

Fish oil lipid emulsion (LE) vs S‐LE

All fish oil containing LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 1.28 [0.69, 2.35]
  5 studies · 399 participants
  Low

Alternative lipid emulsion (LE) vs S‐LE

All alternative LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 1.17 [0.66, 2.07]
  7 studies · 623 participants
  Low

MFS‐LE vs S‐LE

MFS‐LE showed no clear difference in death before discharge compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 5 [0.25, 99.95]
  1 study · 60 participants
  Low

OS‐LE vs S‐LE

OS‐LE showed no clear difference in death before discharge(incidence) compared with S‐LE (low certainty).

• Alternative lipid emulsions versus pure soy oil based lipid emulsions for parenterally fed preterm infants 2015 · Cochrane Headline outcomes only
  RR 1 [0.21, 4.82]
  3 studies · 224 participants
  Low

Alternative lipid emulsion (LE) vs S‐LE

Alternative lipid emulsion (LE) showed no clear difference in death before discharge – OS‐LE vs S‐LE compared with soybean oil‐based LE (S‐LE) (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1 [0.21, 4.82]
  3 studies · 224 participants
  Low

Alternative lipid emulsion (LE) vs S‐LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  GRADE not reported

Alternative lipid emulsion (LE) vs another alternative‐LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 60 participants
  GRADE not reported

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs S‐LE compared with non‐fish oil LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.24 [0.81, 1.9]
  9 studies · 855 participants
  Low

Fish oil lipid emulsion (LE) vs another fish oil LE

Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 1 [0.15, 6.64]
  1 study · 60 participants
  Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 19 participants
  GRADE not reported

Fish oil lipid emulsion (LE) vs non‐fish oil LE

It is very uncertain whether fish oil lipid emulsion (LE) changes death before discharge – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).

• Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
  RR 0.24 [0.03, 1.87]
  2 studies · 40 participants
  Very low