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Evidence found and GRADE certainty

8 questions · 8 findings · 4 reviews · Neonatal

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No studies found 1 · 12.5%GRADE not reported 0 · 0%Very low 2 · 25%Low 2 · 25%Moderate 2 · 25%High 1 · 12.5%

Probiotics administered exclusively after birth in mothers of preterm infants vs placebo or no intervention

Mortality before hospital discharge · preterm infants

Probiotics administered exclusively after birth in mothers of… showed no clear difference in death prior to hospital discharge compared with maternal placebo or no intervention (low certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

All‐cause mortality (outcome collected through first event: death, hospital discharge, hospital transfer, or 120 days after birth) · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in all‐cause mortality (outcome collected through first event: death,… compared with placebo (moderate certainty).

1 finding from 1 review

Inositol supplementation IV initially followed by enteral administration (repeat doses of 80 mg/kg/day) in preterm infants born at less than 30 weeks' PMA vs placebo

BPD or death by it prior to 37 weeks' PMA (outcomes collected through first event: death, hospital discharge, hospital transfer, or 120 days after birth) · preterm infants with or at risk of respiratory distress syndrome

Inositol supplementation IV initially followed by enteral… showed no clear difference in BPD or death by it prior to 37 weeks' PMA (outcomes collected… compared with placebo (high certainty).

1 finding from 1 review