Leflunomide vs methotrexate
Death · adults with renal vasculitis for maintenance therapy
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Findings
What do systematic reviews say?
189 questions · 190 findings · 58 reviews
No studies found 43 · 22.6%GRADE not reported 14 · 7.4%Very low 53 · 27.9%Low 44 · 23.2%Moderate 27 · 14.2%High 9 · 4.7%
An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)
HIV Transmission or Death at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers
An extended NVP regimen administered to infants for 14 weeks probably leads to lower HIV Transmission or Death at 24 months among those uninfected at… compared with sdNVP plus ZDV (1week) (moderate certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyHR 0.71 [0.58, 0.87]1 study · 1129 participantsModerate
A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered
HIV transmission or death at 6 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers
A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission or death at 6 months among all infants whose HIV… compared with a once‐daily NVP regimen administered (low certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyHR 0.7 [0.38, 1.31]1 study · 1522 participantsLow
A once‐daily NVP regimen administered for 6 months vs a once‐daily NVP regimen administered
HIV transmission or death at 12 months among all infants whose HIV diagnostic testing was negative within 6 weeks of birth · Breastfeeding infants of HIV‐infected mothers
A once‐daily NVP regimen administered for 6 months showed no clear difference in HIV transmission or death at 12 months among all infants whose HIV… compared with a once‐daily NVP regimen administered (moderate certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyHR 0.66 [0.42, 1.05]1 study · 1522 participantsModerate
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)
HIV Transmission or Death at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers
An extended NVP plus ZDV regimen administered to infants for 14 weeks probably leads to lower HIV Transmission or Death at 24 months among those uninfected at birth compared with sdNVP plus ZDV (1 week) (moderate certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyHR 0.73 [0.6, 0.9]1 study · 1123 participantsModerate
An extended NVP regimen administered to infants for 28 weeks vs 1 week of antiretroviral prophylaxis
HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · Breastfeeding infants of HIV‐infected mothers
An extended NVP regimen administered to infants for 28 weeks probably leads to lower HIV transmission or death at 28 weeks among those whose diagnostic… compared with 1 week of antiretroviral prophylaxis (moderate certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyRR 0.38 [0.22, 0.65]1 study · 1447 participantsModerate
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants
HIV Transmission or Death at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers
An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in HIV Transmission or Death at 24 months among those uninfected at birth compared with an extended NVP regimen administered to infants (moderate certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyHR 1 [0.75, 1.34]1 study · 1122 participantsModerate
An extended NVP regimen administered to infants for 6 weeks vs sdNVP
HIV Transmission or Death at 6 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers
An extended NVP regimen administered to infants for 6 weeks probably leads to lower HIV Transmission or Death at 6 months among those whose HIV… compared with sdNVP (moderate certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyRR 0.72 [0.54, 0.95]1 study · 1887 participantsModerate
An extended NVP regimen administered to infants for 6 weeks vs sdNVP
HIV Transmission or Death at 12 months among those whose HIV diagnostic testing was negative within 7 days of birth · Breastfeeding infants of HIV‐infected mothers
An extended NVP regimen administered to infants for 6 weeks showed no clear difference in HIV Transmission or Death at 12 months among those whose HIV… compared with sdNVP (moderate certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyRR 0.79 [0.61, 1.01]1 study · 1883 participantsModerate
An extended NVP regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)
HIV Transmission or Death at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers
An extended NVP regimen administered to infants for 14 weeks leads to lower HIV Transmission or Death at 9 months among those whose HIV… compared with sdNVP plus ZDV (1week) (high certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyHR 0.69 [0.55, 0.87]1 study · 2019 participantsHigh
An extended antiretroviral regimen administered to mothers for 28 weeks vs 1 week of antiretroviral prophylaxis
HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · HIV‐infected mothers and their breastfeeding infants
An extended antiretroviral regimen administered to mothers for 28… probably leads to lower HIV transmission or death at 28 weeks among those whose diagnostic… compared with 1 week of antiretroviral prophylaxis (moderate certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyRR 0.61 [0.38, 0.96]1 study · 1435 participantsModerate
An extended antiretroviral regimen administered to mothers for 28 weeks vs an extended NVP regimen administered to infants
HIV transmission or death at 28 weeks among those whose diagnostic test was negative at 2 weeks · HIV‐infected mothers and their breastfeeding infants
An extended antiretroviral regimen administered to mothers for 28… showed no clear difference in HIV transmission or death at 28 weeks among those whose diagnostic… compared with an extended NVP regimen administered to infants (moderate certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyRR 1.6 [0.91, 2.82]1 study · 1618 participantsModerate
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs sdNVP plus ZDV (1 week)
HIV Transmission or Death at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers
An extended NVP plus ZDV regimen administered to infants for 14 weeks leads to lower HIV Transmission or Death at 9 months among those whose HIV… compared with sdNVP plus ZDV (1 week) (high certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyHR 0.72 [0.57, 0.9]1 study · 2000 participantsHigh
An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants
HIV Transmission or Death at 9 months among those whose HIV diagnostic testing was negative within 48 hours of birth · Breastfeeding infants of HIV‐infected mothers
An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in HIV Transmission or Death at 9 months among those whose HIV… compared with an extended NVP regimen administered to infants (moderate certainty).
1 finding from 1 review
- Antiretroviral interventions for preventing breast milk transmission of HIV 2014 · Cochrane Headline outcomes onlyHR 1.09 [0.82, 1.44]1 study · 2013 participantsModerate
Azathioprine vs cyclophosphamide
Death (all causes) · adults with renal vasculitis for maintenance therapy
Azathioprine showed no clear difference in death (median compared with cyclophosphamide (moderate certainty).
1 finding from 1 review
- RR 0.77 [0.35, 1.72]1 study · 144 participantsModerate
Antibiotics vs placebo
Death at 6 months · adults with renal vasculitis for maintenance therapy
Antibiotics showed no clear difference in death at 6 months compared with placebo (low certainty).
1 finding from 1 review
- RR 0.33 [0.01, 7.76]1 study · 81 participantsLow
Surgical thrombectomy vs mechanical thrombectomy
Death · thrombosed haemodialysis arteriovenous fistulas and grafts
It is very uncertain whether surgical thrombectomy changes death compared with mechanical thrombectomy (very low certainty).
1 finding from 1 review
- Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes onlyRR 1.15 [0.17, 7.99]1 study · 153 participantsVery low
Mechanical thrombectomy vs pulse spray technique
Death · thrombosed haemodialysis arteriovenous fistulas and grafts
It is very uncertain whether mechanical thrombectomy changes death compared with pulse spray technique (very low certainty).
1 finding from 1 review
- Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes onlyRR 6.56 [0.35, 124.23]1 study · 120 participantsVery low
Mechanical thrombectomy vs continuous infusion
Death · thrombosed haemodialysis arteriovenous fistulas and grafts
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Surgical thrombectomy vs continuous infusion
Death · thrombosed haemodialysis arteriovenous fistulas and grafts
The review found no eligible studies for this question.
1 finding from 1 review
- Interventions for thrombosed haemodialysis arteriovenous fistulas and grafts 2024 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found