Findings

What do systematic reviews say?

95 questions · 96 findings · 37 reviews · Headline outcomes only

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No studies found 24 · 25%GRADE not reported 1 · 1%Very low 30 · 31.3%Low 21 · 21.9%Moderate 12 · 12.5%High 8 · 8.3%

Corticosteroids vs no corticosteroid use

Incidence of any serious adverse effects attributable to the administration of corticosteroids · children diagnosed with Kawasaki disease

1 finding from 1 review

Corticosteroids for the treatment of Kawasaki disease in children 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 737 participants
Moderate

Inhaled corticosteroids vs placebo

Open‐label use of systemic corticosteroids · preterm infants

It is very uncertain whether inhaled corticosteroids changes open‐label use of systemic corticosteroids compared with placebo (very low certainty).

1 finding from 1 review

Late (≥ 7 days) inhaled corticosteroids to reduce bronchopulmonary dysplasia in preterm infants 2022 · Cochrane Headline outcomes only
RR 0.51 [0.26, 1]
4 studies · 74 participants
Very low

Summary of findings table ‐ Repeat dose(s) of prenatal corticosteroids vs single course

Corticosteroid related adverse events · the woman

1 finding from 1 review

Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 1477 participants
Low

Systemic or topical corticosteroids vs placebo or control

Risk of secondary hemorrhage; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids may leads to lower risk of secondary hemorrhage; oral corticosteroids compared with placebo or control treatment (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 0.63 [0.4, 0.97]
3 studies · 323 participants
Low

Systemic or topical corticosteroids vs placebo or control

Risk of secondary hemorrhage; topical corticosteroids · people with traumatic hyphema

It is very uncertain whether systemic or topical corticosteroids changes risk of secondary hemorrhage; topical corticosteroids compared with placebo or control treatment (very low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 0.29 [0.05, 1.53]
2 studies · 151 participants
Very low

Systemic or topical corticosteroids vs placebo or control

Time to resolution of primary hemorrhage · people with traumatic hyphema

2 findings from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 166 participants
Low
Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 34 participants
Very low

Systemic or topical corticosteroids vs placebo or control

Final visual acuity between 20/20 and 20/40 at end of treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in final visual acuity between 20/20 and 20/40 at end of treatment;… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 1.01 [0.84, 1.23]
1 study · 41 participants
Low

Systemic or topical corticosteroids vs placebo or control

Final visual acuity between 20/20 and 20/25 at end of treatment; topical corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in final visual acuity between 20/20 and 20/25 at end of treatment;… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 1.02 [0.94, 1.11]
1 study · 111 participants
Low

Systemic or topical corticosteroids vs placebo or control

Short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 1.2 [0.97, 1.49]
2 studies · 277 participants
Low

Systemic or topical corticosteroids vs placebo or control

Short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after treatment; topical corticosteroids · people with traumatic hyphema

It is very uncertain whether systemic or topical corticosteroids changes short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after… compared with placebo or control treatment (very low certainty).

1 finding from 1 review

Medical interventions for traumatic hyphema 2023 · Cochrane Headline outcomes only
RR 0.75 [0.38, 1.47]
1 study · 34 participants
Very low

Increased vs stable doses of inhaled corticosteroids

Treatment failure ‐ need for systemic corticosteroids (ITT) · adults and children with chronic asthma

Increased showed no clear difference in treatment failure: need for systemic corticosteroids (ITT) compared with stable doses of inhaled corticosteroids (moderate certainty).

1 finding from 1 review

Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children 2022 · Cochrane Headline outcomes only
OR 0.97 [0.76, 1.25]
8 studies · 1774 participants
Moderate

Increased vs stable doses of inhaled corticosteroids

Treatment failure ‐ need for systemic corticosteroids (of those starting inhaler) · adults and children with chronic asthma

It is very uncertain whether increased changes treatment failure: need for systemic corticosteroids (of those… compared with stable doses of inhaled corticosteroids (very low certainty).

1 finding from 1 review

Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children 2022 · Cochrane Headline outcomes only
OR 0.84 [0.54, 1.3]
7 studies · 766 participants
Very low

Intervention not reported

Corticosteroids · adults undergoing any type of surgery under general anaesthesia Interventions: antiemetic drugs (monoprophylaxis and combination…