What do systematic reviews say?

Dietary advice vs dietary advice plus oral nutritional supplements

Dietary advice may leads to lower complications compared with dietary advice plus oral nutritional supplements (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.75 [0.56, 0.99]
  3 studies · 317 participants
  Low

Dietary advice plus supplements vs no advice

Dietary advice plus supplements if required showed no clear difference in complications compared with no advice (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.56 [0.22, 1.46]
  2 studies · 280 participants
  Low

Dietary advice plus supplements vs no dietary advice plus no supplements

Dietary advice plus supplements may leads to lower complications compared with no dietary advice plus no supplements (low certainty).

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  RR 0.42 [0.2, 0.89]
  1 study · 50 participants
  Low

Dietary advice vs no advice

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 148 participants
  Low

Dietary advice vs oral nutritional supplements

The review found no eligible studies for this question.

• Dietary advice with or without oral nutritional supplements for disease‐related malnutrition in adults 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings for nasal irrigation with topical steroids plus sinus surgery vs nasal irrigation with topical steroids alone

• Surgery for nasal polyposis in cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 28 participants
  Very low

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

The review found no eligible studies for this question.

• Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Preoperative blood transfusion vs no transfusion

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 434 participants
  GRADE not reported

Summary of findings ‐ Pfaffia paniculata vs placebo

• Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 30 participants
  Very low

Summary of findings ‐ Niprisan® vs placebo

• Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  70 participants
  Low

Summary of findings ‐ Ciklavit® vs placebo

The review found no eligible studies for this question.

• Phytomedicines (medicines derived from plants) for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Preoperative blood transfusion vs no transfusion

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 434 participants
  Very low

L‐arginine vs placebo

The review found no eligible studies for this question.

• Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Omega‐3 vs placebo

The review found no eligible studies for this question.

• Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Preoperative blood transfusion vs no transfusion

Preoperative blood transfusion showed no clear difference in perioperative complications ‐ any surgery‐related compared with no transfusion (low certainty).

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  RR 0.24 [0.03, 2.05]
  1 study · 65 participants
  Low

Intervention not reported

The review found no eligible studies for this question.

• Enzyme replacement therapy for Anderson‐Fabry disease 2016 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Preoperative blood transfusion vs no transfusion

It is very uncertain whether preoperative blood transfusion changes serious complications related to SCD ‐ painful crises compared with no transfusion (very low certainty).

• Preoperative blood transfusions for sickle cell disease 2020 · Cochrane Headline outcomes only
  OR 1.91 [0.61, 6.04]
  2 studies · 434 participants
  Very low

Intervention not reported

• Enzyme replacement therapy for Anderson‐Fabry disease 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 82 participants
  Very low

Intervention not reported

• Enzyme replacement therapy for Anderson‐Fabry disease 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 29 participants
  Very low

Dalteparin vs placebo

The review found no eligible studies for this question.

• Low‐molecular‐weight heparins for managing vaso‐occlusive crises in people with sickle cell disease 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found