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What do systematic reviews say?

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Evidence found and GRADE certainty

4 questions · 4 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 25%Low 1 · 25%Moderate 2 · 50%High 0 · 0%

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (moderate certainty).

1 finding from 1 review

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · Women undergoing controlled ovarian stimulation in IVF and ICSI cycles (poor responders)

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonist or midcycle antagonist) (low certainty).

1 finding from 1 review

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

1 finding from 1 review · compare the 2 reviews