Findings

What do systematic reviews say?

6 questions · 6 findings · 4 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 33.3%Low 1 · 16.7%Moderate 3 · 50%High 0 · 0%

GnRH agonists vs GnRH antagonists

Clinical pregnancy rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

GnRH agonists probably leads to lower clinical pregnancy rate compared with gnRH antagonists (moderate certainty).

1 finding from 1 review

Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
OR 0.62 [0.42, 0.9]
1 study · 473 participants
Moderate

GnRH agonists vs control

Clinical pregnancy rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

GnRH agonists showed no clear difference in clinical pregnancy rate compared with control (low certainty).

1 finding from 1 review

Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
OR 1.08 [0.82, 1.43]
8 studies · 1289 participants
Low

GnRH agonists vs placebo

Clinical pregnancy rate · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

It is very uncertain whether among different GnRH agonists changes clinical pregnancy rate compared with placebo (very low certainty).

1 finding from 1 review

Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
OR 1.93 [0.62, 5.98]
1 study · 50 participants
Very low

Gonadotropins with GnRH agonists vs gonadotropins alone

Clinical pregnancy rate · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether gonadotropins with GnRH agonists changes clinical pregnancy rate per couple compared with gonadotropins alone (very low certainty).

1 finding from 1 review

Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
OR 0.55 [0.32, 0.95]
3 studies · 355 participants
Very low

GnRH antagonist vs long‐course GnRH agonist

Clinical pregnancy rate · women undergoing assisted reproductive technology (ART)

GnRH antagonist showed no clear difference in clinical pregnancy rate per woman randomised compared with long‐course GnRH agonist (moderate certainty).

1 finding from 1 review

Gonadotrophin‐releasing hormone antagonists for assisted reproductive technology 2016 · Cochrane Headline outcomes only
OR 0.91 [0.83, 1]
54 studies · 9959 participants
Moderate

Clomiphene citrate or letrozole with or without gonadotropins (with or without midcycle antagonist) vs gonadotropins (with GnRH agonists or midcycle antagonist)

Clinical pregnancy rate · for controlled ovarian stimulation

Clomiphene citrate or letrozole with or without gonadotropins (with… showed no clear difference in clinical pregnancy rate per woman compared with gonadotropins (with GnRH agonists or midcycle antagonist) (moderate certainty).

1 finding from 1 review

Oral medications including clomiphene citrate or aromatase inhibitors with gonadotropins for controlled ovarian… 2017 · Cochrane Headline outcomes only
RR 1 [0.86, 1.16]
12 studies · 1998 participants
Moderate