Findings

What do systematic reviews say?

24 questions · 24 findings · 15 reviews

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No studies found 2 · 8.3%GRADE not reported 0 · 0%Very low 10 · 41.7%Low 10 · 41.7%Moderate 2 · 8.3%High 0 · 0%

Assisted hatching vs no assisted hatching

Clinical pregnancy rate · women undergoing assisted reproduction

Assisted hatching may leads to higher clinical pregnancy rate per woman randomised compared with no assisted hatching (low certainty).

1 finding from 1 review

Assisted hatching on assisted conception (in vitro fertilisation (IVF) and intracytoplasmic sperm injection (ICSI)) 2021 · Cochrane Headline outcomes only
OR 1.2 [1.09, 1.33]
39 studies · 7249 participants
Low

Metformin vs placebo or no treatment

Clinical pregnancy rate per woman ‐ long protocol GnRH‐agonist · women with polycystic ovary syndrome

Metformin may leads to higher clinical pregnancy rate per woman ‐ long protocol GnRH‐agonist compared with placebo or no treatment (low certainty).

1 finding from 1 review

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 1.32 [1.08, 1.63]
10 studies · 915 participants
Low

Metformin vs placebo or no treatment

Clinical pregnancy rate · women with polycystic ovary syndrome

It is very uncertain whether metformin changes clinical pregnancy rate per woman ‐ short protocol GnRH‐antagonist compared with placebo or no treatment (very low certainty).

1 finding from 1 review · compare the 2 reviews

Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome 2020 · Cochrane Headline outcomes only
RR 1.38 [0.21, 9.14]
2 studies · 177 participants
Very low

Cyst aspiration vs conservative management

Clinical pregnancy · women with subfertility

It is very uncertain whether cyst aspiration changes clinical pregnancy rate Ultrasound diagnosis of intrauterine pregnancy compared with conservative management (very low certainty).

1 finding from 1 review

Ovarian cyst aspiration prior to in vitro fertilization treatment for subfertility 2014 · Cochrane Headline outcomes only
OR 1.19 [0.33, 4.29]
2 studies · 159 participants
Very low