What do systematic reviews say?

Summary of findings: Iron vs placebo

• Iron for the treatment of restless legs syndrome 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 128 participants
  Very low

SPRM vs placebo

• Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 171 participants
  Moderate

Fexofenadine 120 mg/d vs placebo (1‐week intervention)

The review found no eligible studies for this question.

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Loratadine 10 mg vs placebo (4‐week intervention)

The review found no eligible studies for this question.

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Loratadine 10 mg vs placebo (2‐week intervention)

The review found no eligible studies for this question.

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Cetirizine 0.5 mg/kg/d vs placebo (18‐month intervention)

The review found no eligible studies for this question.

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Cetirizine 10 mg/d vs placebo (4‐week intervention)

The review found no eligible studies for this question.

• Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings: inhaled antioxidants vs placebo

• Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 153 participants
  Moderate

Moisturisers vs vehicle, placebo or no moisturiser

• Emollients and moisturisers for eczema 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 300 participants
  Low

Selenium (+LT4) vs placebo (+LT4)

The review found no eligible studies for this question.

• Selenium supplementation for Hashimoto's thyroiditis 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Dornase alfa vs placebo or no dornase alfa treatment

Dornase alfa showed no clear difference in change in quality of life ‐ CFQ‐R respiratory at 1 month compared with placebo or no dornase alfa treatment (low certainty).

• Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
  MD 0.84
  19 participants
  Low
• Dornase alfa for cystic fibrosis 2021 · Cochrane Headline outcomes only
  MD 9.78
  19 participants
  Low

Summary of findings table ‐ Cannabis vs placebo

• Cannabis and cannabinoids for symptomatic treatment for people with multiple sclerosis 2022 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 1942 participants
  Low

Summary of findings: oral antioxidants (NAC/GSH) vs placebo

• Antioxidant supplementation for lung disease in cystic fibrosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 61 participants
  Moderate

Omega‐3 vs placebo

• Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Group B antipsychotic drugs: olanzapine + supportive intervention vs placebo or supportive treatment

• Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Group A: amino acids vs placebo

• Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

SPRM vs placebo

• Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 200 participants
  Moderate

Spironolactone 100 mg vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Finasteride 5 mg to 7.5 mg vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Metformin 500 mg to 2550 mg per day vs placebo

The review found no eligible studies for this question.

• Interventions for hirsutism (excluding laser and photoepilation therapy alone) 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found