Metronidazole gel 25% (local antibiotic) showed no clear difference in change in probing pocket depth compared with ultrasonic debridement; GRADE not reported.
Er:YAG laser showed no clear difference in change in probing pocket depth compared with air-abrasive device (Perio-Flow); GRADE not reported.
Mechanical debridement with titanium curettes showed no clear difference in change in probing pocket depth compared with mechanical debridement with ultrasonic device; GRADE not reported.
Sonic toothbrushing showed no clear difference in change in probing pocket depth compared with manual toothbrushing; GRADE not reported.
Mechanical debridement plus topical minocycline showed no clear difference in change in probing pocket depth compared with mechanical debridement plus chlorhexidine gel; GRADE not reported.
Phosphoric etching (acid) gel showed no clear difference in change in probing pocket depth compared with mechanical debridement and polishing; GRADE not reported.
Hyaluronic acid gel (brushing) showed no clear difference in change in probing pocket depth compared with chlorhexidine gel (brushing); GRADE not reported.
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… led to higher change in probing pocket depth (PPD) compared with subgingival instrumentation (SI) alone (hand or power-driven, or…; GRADE not reported.
Adjunctive antimicrobial photodynamic therapy (aPDT) applied after… showed no clear difference in change in probing pocket depth (PPD) compared with subgingival instrumentation (SI) alone (hand or power-driven, or…; GRADE not reported.
Full-mouth disinfection (FMD): scaling/root planing (subgingival… showed no clear difference in change in probing pocket depth (PPD) compared with quadrant scaling and root planing (control): SRP of each quadrant in… (low certainty).
Full-mouth scaling (FMS): scaling/root planing (subgingival… showed no clear difference in change in probing pocket depth (PPD) compared with quadrant scaling and root planing (control): SRP of each quadrant in… (low certainty).
Full-mouth scaling (FMS): scaling/root planing (subgingival… showed no clear difference in change in probing pocket depth (PPD) compared with full-mouth disinfection (FMD): scaling/root planing (subgingival… (low certainty).
Nanocrystalline hydroxyapatite (Ostim) led to lower change in probing pocket depth (PPD) compared with bovine-derived xenograft (Bio-Oss) plus resorbable barrier; GRADE not reported.
Er:YAG laser debridement showed no clear difference in change in probing pocket depth (PPD) compared with manual debridement plus chlorhexidine irrigation/gel; GRADE not reported.
Adjunctive local antibiotic (8.5% doxycycline hyclate, Atridox)… led to higher change in probing pocket depth (PPD) compared with manual debridement with chlorhexidine (no antibiotic); GRADE not reported.
Enamel matrix derivative (EMD; Emdogain) showed no clear difference in change in probing pocket depth (PPD) compared with guided tissue regeneration (GTR) with barriers (low certainty).
Enamel matrix derivative (EMD; Emdogain) may leads to higher change in probing pocket depth (PPD) compared with placebo or control (same surgical or non-surgical intervention… (low certainty).