Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 2 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Grape seed extract (GSE) and its proanthocyanidin fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms)

Grape seed extract inhibits S. mutans adhesion to hydroxyapatite in vitro (2 studies; ungraded).

1 finding from 1 review

Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a… 2024 All outcomes
in vitro (laboratory)
GSE inhibited S. mutans adhesion to hydroxyapatite by 81.5% (polymeric PAC, 0.125 mg/mL) vs 25% for dealcoholized wine (Daglia); adhesion decreased at MIC 0.5 mg/mL (Smullen).
2 studies
GRADE not reported

Cranberry extract / juice and proanthocyanidin (flavonoid) fractions vs Untreated or vehicle control (some studies vs positive antimicrobial controls, e.g. chlorhexidine/fluoride)

Bacterial adhesion (inhibition) · Streptococcus mutans (in vitro cultures and biofilms)

Cranberry extract inhibits S. mutans adhesion / initial colonization in vitro (3 studies; ungraded).

1 finding from 1 review

Effect of flavonoids from grape seed and cranberry extracts on the microbiological activity of Streptococcus mutans: a… 2024 All outcomes
in vitro (laboratory)
Cranberry formulations adhered to and prevented biofilm on saliva-coated hydroxyapatite (Greene); reduced adhesion via inhibited glucan synthesis (Feng); reduced initial S. mutans colonization 40-60% through reduced…
3 studies
GRADE not reported