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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 2 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 1 · 16.7%High 2 · 33.3%

Inhaled NO vs control

Mortality before hospital discharge · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death before discharge ‐ Studies with entry after 3 days based on… compared with control (high certainty).

1 finding from 1 review

Inhaled NO vs control

Neurodevelopmental disability · respiratory failure in preterm infants

Inhaled NO showed no clear difference in neurodevelopmental disability ‐ Studies with entry after 3 days… compared with control (moderate certainty).

1 finding from 1 review

Inhaled NO vs control

Death or bronchopulmonary dysplasia at 36 weeks PMA · respiratory failure in preterm infants

Inhaled NO showed no clear difference in death or bronchopulmonary dysplasia at 36 weeks ‐ Studies with entry… compared with control (high certainty).

1 finding from 1 review

Inhaled steroids vs systemic corticosteroids

Death or BPD (28 days) · preterm infants with respiratory distress for initial respiratory support

Inhaled steroids showed no clear difference in death or BPD at 28 days compared with systemic corticosteroids (low certainty).

1 finding from 1 review