Findings

What do systematic reviews say?

3 questions · 3 findings · 3 reviews · Hypertension

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 66.7%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%

Antihypertensive drug therapy vs placebo or no treatment

All‐cause mortality · adults (18 years of age or older) with hypertension‐induced left ventricular hypertrophy

It is very uncertain whether antihypertensive therapy changes all‐cause mortality compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension‐induced left ventricular hypertrophy 2021 · Cochrane Headline outcomes only
RR 1.02 [0.74, 1.4]
3 studies · 930 participants
Very low

Antihypertensive drug therapy vs control

All‐cause mortality · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

Antihypertensive drug therapy showed no clear difference in all‐cause mortality compared with control (low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
RR 0.94 [0.77, 1.13]
5 studies · 16776 participants
Low

Evening vs morning dosing regimen

All‐cause mortality · adults with primary (essential) hypertension whose systolic or diastolic (or both) blood pressure levels were 130/80 mmHg or greater

It is very uncertain whether evening changes all‐cause mortality compared with morning dosing regimen (very low certainty).

1 finding from 1 review

Evening versus morning dosing regimen drug therapy for hypertension 2024 · Cochrane Headline outcomes only
RR 0.49 [0.04, 5.42]
1 study · 735 participants
Very low