Findings

What do systematic reviews say?

8 questions · 8 findings · 2 reviews · Headline outcomes only

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No studies found 3 · 37.5%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 50%Moderate 1 · 12.5%High 0 · 0%

N‐acetylcysteine vs placebo

All‐cause mortality · adult patients with non‐paracetamol (acetaminophen)‐related acute liver failure

N‐acetylcysteine showed no clear difference in all‐cause mortality compared with placebo (low certainty).

1 finding from 1 review

N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure 2020 · Cochrane Headline outcomes only
RR 0.88 [0.57, 1.37]
1 study · 173 participants
Low

N‐acetylcysteine vs placebo

All‐cause mortality · children with non‐paracetamol (acetaminophen)‐related acute liver failure

N‐acetylcysteine showed no clear difference in all‐cause mortality compared with placebo (low certainty).

1 finding from 1 review

N‐acetylcysteine for non‐paracetamol (acetaminophen)‐related acute liver failure 2020 · Cochrane Headline outcomes only
RR 1.47 [0.85, 2.53]
1 study · 184 participants
Low

Paracetamol vs ibuprofen

All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA

Paracetamol showed no clear difference in all‐cause mortality during initial hospital stay(by clinical… compared with ibuprofen (moderate certainty).

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
RR 1.09 [0.8, 1.48]
8 studies · 734 participants
Moderate

Early paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Late paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol plus ibuprofen (oral or IV) vs ibuprofen plus placebo (oral or IV) or no intervention

All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Paracetamol vs indomethacin

All‐cause mortality during hospital stay · preterm infants with PDA

Paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with indomethacin (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.86 [0.39, 1.92]
2 studies · 114 participants
Low

Prophylactic administration of paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm infants with PDA

Prophylactic administration of paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with placebo or no intervention (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.59 [0.24, 1.44]
3 studies · 240 participants
Low