Findings

What do systematic reviews say?

6 questions · 6 findings · 3 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 0 · 0%GRADE not reported 4 · 66.7%Very low 0 · 0%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Uric acid lowering therapies (UAR) vs placebo

Withdrawals due to adverse events · hyperuricaemia in people with hypertension

Uric acid‐lowering drug showed no clear difference in adverse events (withdrawals due to side effects) compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapy for hyperuricaemia in hypertensive patients 2020 · Cochrane Headline outcomes only
RR 1.86 [0.43, 8.1]
3 studies · 241 participants
Low

Summary of findings table ‐ Topical capsaicin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
4 weeks
Three participants from the topical capsaicin group withdrew from the study by Winocur et al 2000 due to the severity of the burning sensation and redness.
1 study · 30 participants
GRADE not reported

Oral gabapentin vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
12 weeks
Four of the participants withdrew from the study by Kimos et al 2007 due to adverse effects, but neither the type of adverse effect nor the trial group was specified.
1 study · 44 participants
GRADE not reported

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
3 months
Two allergic reactions and one severe abdominal pain led to three withdrawals from the intervention group in the study by Nguyen et al 2001.
1 study · 45 participants
GRADE not reported

Oral clonazepam (benzodiazepine) vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
60 days
One participant in the clonazepam group withdrew from the study by Harkins et al 1991 due to severe headache.
1 study · 20 participants
GRADE not reported

Calcium channel blockers vs placebo

Withdrawals due to adverse events · patients with Raynaud's phenomenon

Calcium channel blockers showed no clear difference in number of withdrawals due to adverse events Number of participants… compared with placebo (low certainty).

1 finding from 1 review

Calcium channel blockers for primary and secondary Raynaud's phenomenon 2017 · Cochrane Headline outcomes only
RR 1.3 [0.51, 3.33]
2 studies · 63 participants
Low