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Evidence found and GRADE certainty

1,004 questions · 1,019 findings · 269 reviews

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No studies found 333 · 32.7%GRADE not reported 106 · 10.4%Very low 313 · 30.7%Low 189 · 18.5%Moderate 66 · 6.5%High 12 · 1.2%

Intramedullary fixation vs open reduction and internal fixation with plate

Adverse events ‐ total of adverse events (various: mainly infection; cosmetic result ‐ e.g. prominent metalwork ‐ and symptomatic hardware) · adults (aged ≥ 16 years) with acute middle third clavicle fractures

It is very uncertain whether intramedullary fixation changes adverse events ‐ total of adverse events (various: mainly infection;… compared with open reduction and internal fixation with plate (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events 4 studies reported the frequency of self reported adverse events in the AED and placebo groups The results show a trend in favour of the placebo groups · people with epilepsy and intellectual disability

The intervention showed no clear difference in adverse events 4 studies reported the frequency of self reported… (moderate certainty).

1 finding from 1 review

Application of heat vs application of cold

Adverse events due to treatment Minor adverse events, reported in studies as: exacerbation in pain after treatment; burn as a result of hot‐water immersion, or transient erythema, or adverse effects due to application of ice · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes adverse events due to treatment Minor adverse events, reported in… compared with application of cold (very low certainty).

1 finding from 1 review

Schema therapy vs usual care

Adverse events Assessed by: number of participants with a global negative outcome (e.g. dropping out of therapy, recidivism or being transferred to another facility due to poor treatment response) overall Timing of assessment: over the 3 years · adults with antisocial personality disorder

The review found no eligible studies for this question.

1 finding from 1 review