Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,004 questions · 1,019 findings · 269 reviews

No studies found 333 · 32.7%GRADE not reported 106 · 10.4%Very low 313 · 30.7%Low 189 · 18.5%Moderate 66 · 6.5%High 12 · 1.2%

Oral cyclobenzaprine (muscle relaxant) vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Naproxen vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral celecoxib (COX-2 inhibitor) vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Piroxicam vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral prazepam (benzodiazepine) vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Procedure‐related adverse events within 3 months · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in procedure‐related adverse events within 3 months compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Fractional laser vs radiofrequency

Participant‐assessed adverse events (short‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Suprapubic catheterisation vs intermittent self‐catheterisation

Adverse events (acute complication after surgery)

It is very uncertain whether suprapubic catheterisation changes adverse events (acute complication after surgery) compared with intermittent self‐catheterisation (very low certainty).

1 finding from 1 review

Fractional laser vs radiofrequency

Investigator‐assessed adverse events (short‐term) · people with acne scars

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Withdrawal from intervention due to adverse events · people with severe frostbite injuries
1 finding from 1 review

Intervention not reported

Withdrawal from intervention due to adverse events · people with severe frostbite injuries
1 finding from 1 review

Intervention not reported

Withdrawal from intervention due to adverse events · people with severe frostbite injuries
1 finding from 1 review

Corticosteroid creams/ointments: clobetasol propionate foam vs vehicle foam

Number of participants with any adverse event (primary tolerability outcome) · participants with moderate to severe hand eczema

Corticosteroid creams/ointments: clobetasol propionate foam showed no clear difference in primary: adverse events ‐ at least 1 adverse event compared with vehicle foam (moderate certainty).

1 finding from 1 review

Multi‐component intervention vs other treatments/routine care

Number experiencing adverse effects · the management of chronic obstructive pulmonary disease

It is very uncertain whether multi‐component intervention changes adverse events: number of people experiencing an AE compared with other intervention or routine, usual care or control treatment (very low certainty).

1 finding from 1 review

Rituximab/cyclosporin/prednisolone vs cyclosporin/prednisolone

Adverse events: bronchospasm/treatment discontinued · idiopathic steroid‐resistant nephrotic syndrome in children

It is very uncertain whether rituximab/cyclosporin/prednisolone changes adverse events: bronchospasm/treatment discontinued compared with cyclosporin/prednisolone (very low certainty).

1 finding from 1 review