Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

15 questions · 15 findings · 7 reviews · Headline outcomes only

No studies found 6 · 40%GRADE not reported 0 · 0%Very low 4 · 26.7%Low 1 · 6.7%Moderate 4 · 26.7%High 0 · 0%

Zinc vs placebo

Risk of adverse events, including those that may be due to zinc supplements Duration of · adults and children with colds and/or upper respiratory infections
1 finding from 1 review

Zinc vs placebo

Risk of serious adverse events, including those that may be complications of the common cold · adults and children with colds and/or upper respiratory infections

The review found no eligible studies for this question.

1 finding from 1 review

Zinc vs placebo

Adverse events number of participants hospitalised during the trial · children with cystic fibrosis

Summary of findings: Zinc supplementation showed no clear difference in adverse events number of participants hospitalised during the trial compared with placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children aged less than 6 months with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children with persistent diarrhoea

It is very uncertain whether the intervention changes adverse events (vomiting) (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse events (vomiting) · children with acute diarrhoea

The intervention probably leads to higher adverse events (vomiting) (moderate certainty).

1 finding from 1 review