What do systematic reviews say?

Ibuprofen (single postoperative oral dose; 200 mg to 512 mg) vs paracetamol

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  Study period (immediate postoperative)
  The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
  7 studies
  GRADE not reported

Combined paracetamol plus ibuprofen in a single tablet (e.g. paracetamol 1000 mg/ibuprofen 400 mg or 500/200 mg) vs Single drugs given separately (paracetamol 1000 mg or ibuprofen 400 mg)

• Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth 2013 · Cochrane All outcomes

  Study period (immediate postoperative)
  The majority of adverse events were minor in nature and usually included nausea, vomiting, headaches and dizziness. Side effect profiles have not been included in a meta-analysis as multiple adverse events were…
  2 studies
  GRADE not reported

Oral paracetamol vs placebo

Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.

• Paracetamol for pain relief after surgical removal of lower wisdom teeth 2007 · Cochrane All outcomes

  up to 7 days
  RR 1.19 [0.90, 1.57]
  17 studies · 1645 participants
  GRADE not reported

Ozone applied to the carious lesion (10 or 40 seconds), with a fluoride reductant and oral hygiene/preventive advice vs No ozone, with a fluoride reductant and oral hygiene/preventive advice (as in the intervention group)

• Ozone therapy for the treatment of dental caries 2004 · Cochrane All outcomes

  To 6 months
  Baysan 2003 stated that no adverse events were reported to 6 months; no information was provided by Abu-Naba'a 2003 or Abu-Naba'a 2003pilot.
  1 study
  GRADE not reported

Silver diamine fluoride (SDF) vs Not applicable (single-arm safety outcome)

No serious adverse events (e.g., allergic reactions or toxicity) were reported for SDF across the reviews (ungraded).

• Silver diamine fluoride for managing carious lesions: an umbrella review. 2019 All outcomes
  No serious adverse events, such as allergic reactions or toxicity, were reported. A metallic taste or burning sensation was not reported in any of the studies.
  Studies not reported
  GRADE not reported

Systemic antibiotic (oral penicillin 500 mg) plus analgesic vs Placebo plus analgesic

The review found no eligible studies for this question.

• Antibiotic use for irreversible pulpitis 2019 · Cochrane All outcomes
  Number of adverse events: Outcome not reported.
  Studies not reported
  No studies found

Silver diamine fluoride (SDF) vs Not applicable (single-arm safety outcome)

Black staining of arrested lesions was the main adverse event of SDF (reported by seven reviews); it was generally acceptable to patients (ungraded).

• Silver diamine fluoride for managing carious lesions: an umbrella review. 2019 All outcomes
  Eight systematic reviews reported adverse events; seven reported black staining of arrested carious lesions. Older adults rarely complained; discoloration was acceptable in children, concerning 7% of participants in…
  Studies not reported
  GRADE not reported