Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 0 · 0%Moderate 2 · 50%High 0 · 0%

Adverse events · patients with functional dyspepsia

It is very uncertain whether prokinetic changes adverse events compared with placebo (very low certainty).

1 finding from 1 review

Prokinetics for functional dyspepsia 2018 · Cochrane Headline outcomes only
RR 1.09 [0.95, 1.25]
17 studies · 3811 participants
Very low

Adverse events · patients with functional dyspepsia

It is very uncertain whether other prokinetics changes adverse events compared with domperidone 10mg three times a day (very low certainty).

1 finding from 1 review

Prokinetics for functional dyspepsia 2018 · Cochrane Headline outcomes only
RR 0.69 [0.5, 0.97]
7 studies · 1557 participants
Very low

Adverse events · adults with functional dyspepsia

Proton pump inhibitors plus prokinetics probably leads to lower adverse events compared with prokinetics alone (moderate certainty).

1 finding from 1 review

Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only
RR 0.6 [0.39, 0.93]
2 studies · 407 participants
Moderate

Adverse events · adults with functional dyspepsia

Proton pump inhibitors (PPI) showed no clear difference in adverse events compared with prokinetics (moderate certainty).

1 finding from 1 review

Proton pump inhibitors for functional dyspepsia 2017 · Cochrane Headline outcomes only
RR 1.09 [0.79, 1.49]
5 studies · 1033 participants
Moderate