Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 33 findings · 16 reviews · Neuromuscular

No studies found 3 · 9.1%GRADE not reported 1 · 3%Very low 7 · 21.2%Low 8 · 24.2%Moderate 7 · 21.2%High 7 · 21.2%

Intervention not reported

Adverse events · participants with CTEV (type of case (i.e. whether initial presentation or relapsed) not specified)
1 finding from 1 review

Intervention not reported

Adverse events · participants with CTEV at initial presentation

The intervention may leads to lower adverse events (low certainty).

1 finding from 1 review

Prophylactic perindopril (2 mg to 4 mg daily) vs placebo

Adverse events · boys with DMD, normal cardiac examination and LVEF > 55% at baseline

Prophylactic perindopril (2 mg to 4 mg daily) showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Major adverse events · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations

It is very uncertain whether the intervention changes major adverse events (very low certainty).

1 finding from 1 review

Intervention not reported

Minor adverse events · for effects on cramps, people (other than pregnant women) with muscle cramps (largely older adults); for adverse events, all populations

The intervention showed no clear difference in minor adverse events (low certainty).

1 finding from 1 review