Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

47 questions · 47 findings · 15 reviews · Musculoskeletal

No studies found 17 · 36.2%GRADE not reported 3 · 6.4%Very low 11 · 23.4%Low 7 · 14.9%Moderate 7 · 14.9%High 2 · 4.3%

Antidepressants vs placebo

Total adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant leads to higher total adverse events between 0 and 16 weeks compared with placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo

Serious adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant showed no clear difference in serious adverse events between 0 and 16 weeks compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Proportion of participants who withdrew due to adverse events between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher proportion of participants who withdrew due to adverse events… compared with placebo (moderate certainty).

1 finding from 1 review

Preoperative education vs usual care

Total number of serious adverse events (infection, thrombosis, other serious adverse events · patients with knee replacement surgery

Preoperative education showed no clear difference in total number of serious adverse events (infection, thrombosis, other… compared with usual care (low certainty).

1 finding from 1 review

Preoperative education vs usual care

Total number of serious adverse events (infection, thrombosis, other serious adverse events · hip replacement

It is very uncertain whether preoperative education changes total number of serious adverse events (infection, thrombosis, other… compared with usual care (very low certainty).

1 finding from 1 review

Prefabricated foot orthoses vs shoes

Withdrawals due to adverse events · children with juvenile idiopathic arthritis and flat feet

Prefabricated foot orthoses showed no clear difference in withdrawal due to adverse events compared with shoes; GRADE not reported.

1 finding from 1 review