What do systematic reviews say?

Micro-invasive treatment (proximal sealing or resin infiltration): resin sealant, glass ionomer sealant, polyurethane/adhesive patch, or resin infiltration vs Non-invasive / control treatment

• Micro‐invasive interventions for managing proximal dental decay in primary and permanent teeth 2015 · Cochrane All outcomes

  1 to 3 years
  The four studies that measured adverse events reported no adverse events after micro-invasive treatment (no events in either arm)
  4 studies
  GRADE not reported

Any of the interventions (CR, SE, SW, sealing with sealant materials, Hall Technique, or NRCC) vs Each other, placebo, or no treatment

The review found no eligible studies for this question.

• Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes
  None of the studies reported adverse effects.
  0 studies
  No studies found

Prophylaxis (teeth cleaning) and CHX or iodine-NaF solution application in the dentition of women (mothers) vs placebo

• Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
  Two trials (Dasanayake 1993; Dasanayake 2002) reported adverse events related to topical application of the treatment solutions (other data).
  2 studies
  GRADE not reported

Chlorhexidine varnish vs placebo or no treatment

• Chlorhexidine treatment for the prevention of dental caries in children and adolescents 2015 · Cochrane All outcomes
  One study reported no adverse events for ulcers or tooth staining. One study stated "side-effects due to the CHX treatment were not noted".
  2 studies
  GRADE not reported

Intraglandular botulinum neurotoxin (BoNT) injection vs placebo injection

Type A botulinum toxin showed a borderline, non-significant increase in adverse events versus placebo (RD 0.10, 95% CI 0.00 to 0.21; ungraded subgroup).

• The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's disease: a… 2023 All outcomes

  Approximately 1 month post-injection (one study ~1 week) · Movement-disorder / neurology outpatient care (trials from Italy, USA, and Estonia) · BoNT type A
  RD 0.10 [0.00, 0.21]
  5 studies · 117 participants
  GRADE not reported
• The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's disease: a… 2023 All outcomes

  Approximately 1 month post-injection (one study ~1 week) · Movement-disorder / neurology outpatient care (trials from Italy, USA, and Estonia)
  RD 0.15 [0.05, 0.24]
  10 studies · 249 participants
  Low
• The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's disease: a… 2023 All outcomes

  Approximately 1 month post-injection (one study ~1 week) · Movement-disorder / neurology outpatient care (trials from Italy, USA, and Estonia) · BoNT type B
  RD 0.18 [0.04, 0.33]
  5 studies · 132 participants
  GRADE not reported

Silver diamine fluoride (SDF) vs Other methods (pooled: ART/glass ionomer cement, nano-silver fluoride, sodium fluoride varnish, placebo)

SDF commonly causes black staining of arrested lesions; only mild, transient adverse events were reported, with no major adverse events (ungraded).

• The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and… 2024 All outcomes

  up to 30 months · Children/adults with dental caries; multiple countries; community/clinic care setting not clearly specified
  Black staining of arrested lesions reported in most studies; 4 studies reported mild transient events (gingival blenching/pain; diarrhea/stomachache; burning, bad taste, pain, mouth injury, dissatisfaction with…
  Studies not reported
  GRADE not reported